Clinical observations of spondyloarthrites in monozygous twins in the Republic of Karelia
Abstract. In developed countries, the prevalence of spondyloarthrites (SpA) among adult population is estimated as 0.54%. Etiology of this group of diseases is not fully understood, but most studies confirm a strong genetic component in their development. SpA diagnosing is a complex problem in therapeutic and rheumatology practice, and referral to a specialist and making the diagnosis are often delayed for several years. Diagnostic difficulties are taking place due to both the low specificity of the disease’s symptoms and the lack of completely reliable biomarkers. In this situation, the analysis of patient’s family history of SpA can help the “first-contact physician” suspect a disease belonging to SpA group and promptly refer the patient for consultation with rheumatologist. Current article describes our experience observing pairs of monozygotic twins having SpA in the Republic of Karelia.Marusenko I.M., Polskaya I.I., Koryakova N.V.
Keywords
spondyloarthritis
genetics
monozygotic twins
family history
diagnosis of spondyloarthritis
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About the Authors
Irina M. Marusenko, MD, Dr. Sci. (Medicine), professor of the Department of hospital therapy of the Medical institute, Petrozavodsk State University. Address: 185910, Petrozavodsk, 33 Lenina Avenue.E-mail: imarusenko@yandex.ru
ORCID: https://orcid.org/0000-0001-5407-2622
Irina I. Polskaya, MD, PhD (Medicine), senior lecturer of the Department of hospital therapy of the Medical institute, Petrozavodsk State University. Address: 185910, Petrozavodsk, 33 Lenina Avenue.
E-mail: irina_polskaya82@mail.ru
ORCID: https://orcid.org/0000-0002-4122-5551
Nina V. Koryakova, MD, PhD (Medicine), associate professor, associate professor of the Department of hospital therapy of the Medical institute, Petrozavodsk State University. Address: 185910, Petrozavodsk, 33 Lenina Avenue.
E-mail: tnk28@inbox.ru
ORCID: https://orcid.org/0000-0002-8931-2435
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