Diagnosis of extraintestinal manifestations of inflammatory bowel disease: A review
Abstract. Current study is devoted to the analysis of clinical and laboratory approaches to diagnosing extraintestinal manifestations of inflammatory bowel disease (IBD). According to the review, IBD diagnosis is currently based primarily on clinical assessment, physical examination data, instrumental research methods, and the use of standardized classification criteria, while laboratory methods are auxiliary and primarily used for differential diagnostic purposes. Moreover, data of scientific literature demonstrates the systemic nature of IBD and points out to the potential for further exploration of non-invasive biomarkers reflecting the activity of extraintestinal manifestations and disease prognosis. Studying immune-inflammatory mechanisms underlying systemic lesions in case of IBD, as well as assessing the potential of extraintestinal manifestations as predictors of the underlying disease, may contribute to the improvement of diagnostic and therapeutic strategies in this patient population.L.V. Tarasova, Yu.V. Tsyganova, A.A. Nikolaev
Keywords
inflammatory bowel disease
extraintestinal manifestations of inflammatory bowel disease
inflammatory bowel disease biomarkers
endothelial dysfunction
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About the Authors
Larisa V. Tarasova, MD, Dr. Sci. (Medicine), professor, head of the Department of hospital therapy, I.N. Ulyanov Chuvash State University, Cheboksary, Russian Federation.E-mail: tlarisagast18@mail.ru
ORCID: https://orcid.org/0000-0003-1496-0689. Scopus ID: 35777248600. eLibrary SPIN: 4125-7935.
Yulia V. Tsyganova, MD, PhD (Medicine), associate professor of the Department of hospital therapy, I.N. Ulyanov Chuvash State University, Cheboksary, Russian Federation.
E-mail: j.v.tsyganova@mail.ru
ORCID: https://orcid.org/0000-0002-8339-9496. Scopus ID: 57224221651. eLibrary SPIN: 9373-7120.
Anton A. Nikolaev, MD, assistant at the Department of hospital therapy, I.N. Ulyanov Chuvash state university, Cheboksary, Russian Federation.
E-mail: anton_nikolaev_2001@mail.ru
ORCID: https://orcid.org/0000-0002-4534-999X. eLibrary SPIN: 9895-2042
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