Diagnostic and prognostic significance of endothelial dysfunction biochemical markers in patients with discirculatory encephalopathy after COVID-19
Abstract. Cerebrovascular diseases and COVID-19 are comorbid conditions. Endothelial dysfunction is one of the pathogenetic mechanisms for cerebrovascular diseases and COVID-19 development. Laboratory feature of endothelial dysfunction is a change in the level of endothelial dysfunction biochemical markers in the blood serum of patients. The aim: to study the diagnostic and prognostic value of biochemical markers of endothelial dysfunction in patients with dyscirculatory encephalopathy (DE) who underwent COVID-19. Material and methods. For the period from 03/01/22 to 05/31/22, 172 patients were examined, including 137 (79,6%) female and 35 (20.4%) male patients who had COVID-19 and are being examined at the base polyclinic No. 2 of the Central clinical medical and sanitary unit named after honored doctor of Russia V.A. Egorov, Ulyanovsk. Median time from the onset of COVID-19 to examination was 4.8 months. DE was not found in 6% of patients who underwent COVID-19, stage I DE was present in 45%, stage II in 27%, stage III in 22% of participants of the study. Blood sampling was carried out once during the all examination period. Levels of vasculoendothelial growth factor (VEGFA), interleukins 6, 10, 18, tumor necrosis factor-alpha, and monocytic chemotactic protein 1 were studied in blood serum. The Mann–Whitney U-test was used to test the hypothesis of a difference in the samples of patient groups. For all types of statistical analysis, differences were considered to be significant at the achieved significance level p <0,05. Results. According to our research, with an increase of the age of patients who have undergone COVID-19, and the DE stage the level of VEGFA in serum was also increasing (p <0,05). Conclusion. From studied cytokines, the predictive role as a marker of endothelial dysfunction was shown by VEGFA. Its high level in blood serum is associated with the age of DE patients, who have undergone COVID-19, and with the stage of DE they had.Mashin V.V., Dolgova D.R., Belova L.A., Kotova E. Yu., Kruglova L.R., Statenina A.P., Kozin A.A., Israfilova R.R., Martynova D.K.
Keywords
endothelial dysfunction
endothelial dysfunction markers
COVID-19
discirculatory encephalopathy
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About the Authors
Viktor V. Mashin, MD, professor, head of the Department of neurology, neurosurgery and medical rehabilitation, Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: victor_mashin@mail.ru. ORCID: https://orcid.org/0000-0003-0085-3727Dinara R. Dolgova, PhD in Biological Sciences, associate professor of the Department of physiology and pathophysiology, director of Scientific research physicobiological center, Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: dolgova.dinara@yandex.ru. ORCID: https://orcid.org/0000-0001-5475-7031
Lyudmila A. Belova, MD, professor, dean of the Faculty of medicine of the Institute of medicine, ecology and physical culture, Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: labelova@mail.ru. ORCID: https://orcid.org/0000-0002-9585-5604
Elena Yu. Kotova, PhD in Medical Sciences, associate professor of the Department of neurology, neurosurgery and medical rehabilitation, Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: ko-tovatv@mail.ru. ORCID: https://orcid.org/0009-0004-2293-3183
Landysh R. Kruglova, postgraduate student of the Department of neurology, neurosurgery and medical rehabilitation, Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: lali.04@bk.ru. ORCID: https://orcid.org/0009-0008-9665-6915
Anastasia P. Statenina, student of the Faculty of medicine named after T.Z. Biktimirov of the Institute of medicine, ecology and physical culture (group LD-O-19/3), Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: nastya.statenina@mail.ru
Andrey A. Kozin, student of the Faculty of medicine named after T.Z. Biktimirov of the Institute of medicine, ecology and physical culture (group LD-O-17/6), Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: supervaclove@gmail.ru
Rumiya R. Israfilova, student of the Faculty of medicine named after T.Z. Biktimirov of the Institute of medicine, ecology and physical culture (group LD-O-18/9), Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: israfilovarr@gmail.ru
Daria K. Martynova, student of the Faculty of medicine named after T.Z. Biktimirov of the Institute of medicine, ecology and physical culture(group LD-O-18/11), Ulyanovsk State University. Address: 4321017, Ulyanovsk, 42 L. Tolstogo Str. E-mail: martynova.daria2000@yandex.ru
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