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2026№7

Synergism of metabolic disorders: Diabetes mellitus and obesity as key determinants of sudden cardiac death risk

DOI
https://dx.doi.org/10.18565/therapy.2026.7.82-91

N.Yu. Shimokhina, M.M. Petrova, M.P. Rybakova, A.E. Potekhina, V.F. Aziralova, E.A. Chumakova

Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
Abstract. Epidemics of obesity and type 2 diabetes mellitus (T2DM) are associated with an increased incidence of sudden cardiac death (SCD). It is known that these diseases have a negative impact at cardiac structure and function due to associated cardiac tissue remodeling, metabolic dysregulation, inflammation, and oxidative stress. Human atrial tissue biopsy data demonstrate altered cardiomyocyte lipid content and signs of mitochondrial dysfunction in individuals with obesity and T2DM. The increased risk of SCD in this patient population may also be associated with excess lipid deposition in the heart and insulin resistance. Despite significant advance in understanding the pathogenesis of SCD in case of obesity and T2DM, the optimal strategy for identifying patients at high risk for this complication remains unresolved. The aim of the review is to analyze and summarize current data on the pathogenetic relationship between T2DM and obesity, as well as to assess their impact on the increased risk of SCD.

Keywords

sudden cardiac death
type 2 diabetes mellitus
obesity
atherosclerosis
cardiomyopathy
Full text (in Russian)

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About the Authors

Natalya Yu. Shimokhina, MD, Dr. Sci. (Medicine), professor of the Department of outpatient therapy and family medicine with postgraduate education, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation.
E-mail: doctorkardiolog99@rambler.ru
ORCID: https://orcid.org/0000-0002-0091-5265. eLibrary SPIN: 4910-4136.
Marina M. Petrova, MD, Dr. Sci. (Medicine), professor, head of the Department of outpatient therapy and family medicine with postgraduate education, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation.
E-mail: stk99@yandex.ru
ORCID: https://orcid.org/0000-0002-8493-0058. eLibrary SPIN: 3531-2179.
Mariya P. Rybakova, MD, first-year clinical resident of the Department of outpatient therapy and family medicine with a postgraduate course, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation.
E-mail: mari.rybakova.2000@mail.ru
ORCID: https://orcid.org/0009-0000-5666-2423
Anna E. Potekhina, 6th-year student of the Faculty of general medicine, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation.
E-mail: ffs-97@mail.ru
ORCID: https://orcid.org/0009-0007-3171-5104
Valentina F. Aziralova, 6th-year student of the Faculty of general medicine, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation.
E-mail: believe20in02yourself@gmail.com
Evgeniya A. Chumakova, 6th-year student of the Faculty of general medicine, Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation.
E-mail: e.a.chumakova2002@mail.ru
ORCID: https://orcid.org/0009-0007-8327-9500

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