Estimation of galectin-3 level in female patients with chronic heart failure, type 2 diabetes mellitus, and asymptomatic hyperuricemia
Abstract. Significant prevalence and often chronic heart failure (CHF) late diagnosing in patients with comorbid pathology, including type 2 diabetes mellitus (T2DM) and hyperuricemia, and high mortality rate in this group of patients dictate the need to search for new prognostic biomarkers. The aim: to assess galectin-3 levels and the clinical course of CHF in patients with T2DM and asymptomatic hyperuricemia (AHU). Material and methods. Uric acid and galectin-3 levels, as well as clinical characteristics of the clinical course of the disease, were estimated in 128 patients with CHF. Depending on the presence of T2DM and AHU, the study participants were divided into 4 groups: group 1: CHF + T2DM + AHU (n = 33); group 2: CHF + T2DM (n = 35); group 3: CHF + AHU (n = 36); group 4 – CHF without T2DM and AHU (n = 24). Results. Patients with diabetes and glomerular filtration rate (GFR) had statistically significantly (p <0.05) higher levels of uric acid, natriuretic peptide (NT-proBNP), and glomerular filtration rate (GFR), as well as a higher probability of developing retinopathy, neuropathy, and angina pectoris. Moreover, these patients also had higher levels of galectin-3 (p <0.05). Furthermore, the presence of glomerular filtration rate (GFR) alone in combination with CHF increased the risk of developing more severe kidney damage (as was measured by GFR), while the presence of diabetes alone increased the risk of developing cardiac damage (according to NT-proBNP level) (p <0.05). Spearman’s rank correlation analysis revealed the following significant correlations: a high-confidence direct correlation between NT-proBNP and galectin-3 (ρху = 0.837, p < 0.001), markedly tight inverse correlation between left ventricular ejection fraction and NT-proBNP levels (ρху = -0.654, p <0.001), and between left ventricular ejection fraction and galectin-3 levels (ρху = -0.515, p <0.001), also moderate-confidence direct correlation between uric acid level and galectin-3 (ρху = 0.469, p <0.01), and moderate-confidence inverse correlation between uric acid level and GFR (ρху = -0.474, p <0.01). Conclusion. Estimation of galectin-3 level may help predict the risk of cardiovascular diseases associated with AHU in the presence of T2DM, as well as their complications.Kolpacheva M.G., Pashkova A.A., Antakova L.N., Gerasimova O.A., Alferova E.N.
Keywords
chronic heart failure
type 2 diabetes mellitus
hyperuricemia
galectin-3
References
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About the Authors
Marina G. Kolpacheva, MD, assistant at the Department of outpatient therapy, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.E-mail: marina.kolpacheva.1997@mail.ru
ORCID: https://orcid.org/0009-0000-4851-9766. eLibrary SPIN: 8381-0600
Anna A. Pashkova, MD, Dr. Sci. (Medicine), professor, head of the Department of outpatient therapy, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.
E-mail: apashkova@vrngmu.ru
ORCID: https://orcid.org/0009-0002-9026-7763. eLibrary SPIN: 7605-1630
Lyubov N. Antakova, PhD (Biol. Sci.), senior researcher, head of the Department of postgenomic research of the Research Institute of Experimental Biology and Medicine, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.
E-mail: tsvn@bk.ru
ORCID: https://orcid.org/0000-0001-5212-1005. Scopus Author ID: 57212408138. eLibrary SPIN: 3936-3381
Olga A. Gerasimova, PhD (Biol. Sci.), senior researcher at the Research Institute of Experimental Biology and Medicine, N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia. Address: 394036, Voronezh, 10 Studencheskaya St.
E-mail: stavro7@mail.ru
ORCID: https://orcid.org/0000-0001-8662-5279. Scopus Author ID: 57222669198. eLibrary SPIN: 3509-3856. eLibrary SPIN: 3936-3381
Elena N. Alferova, MD, PhD (Medicine), head of the 2nd Department of cardiology, Voronezh City Clinical Emergency Hospital No. 1, cardiologist of the highest category. Address: 23 Patriot Avenue, Voronezh, 394065, Voronezh, 23 Patriotov Avenue.
E-mail: elna_y@mail.ru
ORCID: https://orcid.org/0009-0001-5729-4877
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