Study of unsaturated fatty acids profile in male individuals with obesity, including abdominal obesity, from Novosibirsk region
Abstract. Effects of fatty acids (FA) and mechanisms of changing their profile in human body due to obesity are still remaining understudied and are actively being researched.Shramko V.S., Kashtanova E.V., Shcherbakova L.V., Simonova G.I., Afanasieva A.D., Ragino Yu.I.
The aim: to evaluate plasma unsaturated fatty acid levels in male individuals aged 35–74 years with obesity, including abdominal obesity, in Novosibirsk region, and also to assess the association between FA level and the presence of obesity.
Material and methods. 300 male individuals from rural areas of Novosibirsk region (mean age 56.4 ± 11.5 years) were included into monocentric observational cross-sectional study. Participants with a BMI of 25.0–29.9 kg/m² were considered having overweight, a BMI of 30.0–34.9 kg/m² was considered as a class 1 obesity, BMI of 35.0–39.9 kg/m² was considered as a class 2 obesity, and a BMI ≥ 40 kg/m² was considered as a class 3 obesity. Waist circumference > 94 cm was diagnosed as abdominal obesity. Using gas chromatography with mass-selective detection in blood plasma, the following unsaturated FA were measured: omega-3 alpha-linolenic, eicosapentaenoic, and docosahexaenoic; omega-6 linoleic, gamma-linolenic, dihomo-gamma-linolenic, arachidonic, docosatetraenoic, and docosapentaenoic; omega-9 hexadecenoic, oleic, mead, and selacholic.
Results. Mead FA levels were higher in males with abdominal obesity comparatively to those without this condition. Furthermore, the levels of this FA were statistically significantly different between males with BMI ≥ 25.0 kg/m² and those with normal BMI. Individuals with stage 3 obesity had higher levels of docosahexaenoic and docosapentaenoic acid comparatively to participants with normal BMI (p = 0.023 and p = 0.020, respectively). The probability of obesity was directly associated with increased levels of docosahexaenoic and mead FA, while abdominal obesity was associated with increased mead FA levels (odds ratio 1.054; 95% confidence interval: 1.008–1.101, p = 0.020).
Conclusion. Elevated mead FA level may serve as an additional informative biomarker indicating a high risk of obesity in male individuals.
Keywords
obesity
abdominal obesity
fatty acids
mead acid
docosahexaenoic acid
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About the Authors
Victoria S. Shramko, MD, PhD (Medicine), researcher at the Department of clinical biochemical and hormonal studies of therapeutic diseases, head of the Department of clinical, biochemical, and molecular genetic research methods, Clinic of Research Institute of Internal and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova St.E-mail: Nosova@211.ru
ORCID: https://orcid.org/0000-0002-0436-2549. Scopus ID: 57194556107. eLibrary SPIN: 7626-9238
Elena V. Kashtanova, MD, Dr. Sci. (Biology), associate professor, head of the Department of clinical biochemical and hormonal studies of therapeutic diseases, Research Institute of Internal and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova St.
E-mail: elekastanova@yandex.ru
ORCID: https://orcid.org/0000-0003-2268-4186. Scopus ID: 8645249000. eLibrary SPIN: 3580-2051
Liliya V. Shcherbakova, MD, senior researcher at the Department of clinical, population, and preventive researches of therapeutic and endocrine diseases, head of the extra-budgetary work department, Research Institute of Internal and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova St.
E-mail: 9584792@mail.ru
ORCID: https://orcid.org/0000-0001-9270-9188. Scopus ID: 15030341800. eLibrary SPIN: 5849-7040
Galina I. Simonova, MD, Dr. Sci. (Medicine), professor, chief researcher at the Department of etiopathogenesis and clinic of internal diseases, Research Institute of Internal and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences, Honored Scientist of the Russian Federation. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova St.
E-mail: g.simonova2019@gmail.com
ORCID: https://orcid.org/0000-0002-4030-6130
Alena D. Afanasieva, MD, PhD (Medicine), head of the Department of genetic and environmental determinants of the human life cycle, Research Institute of Internal and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences, Honored Scientist of the Russian Federation. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova St.
E-mail: alene.elene@gmail.com
ORCID: https://orcid.org/0000-0001-7875-1566. Scopus ID: 57221943610. eLibrary SPIN: 7446-4732
Yulia I. Ragino, MD, Dr. Sci. (Medicine), professor, corresponding member of RAS, chief researcher at the Department of clinical biochemical and hormonal studies of therapeutic diseases, Research Institute of Internal and Preventive Medicine – a branch of Federal Research Center Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences, Honored Scientist of the Russian Federation. Address: 630089, Novosibirsk, 175/1 Borisa Bogatkova St.
E-mail: ragino@mail.ru
ORCID: https://orcid.org/0000-0002-4936-8362. Scopus ID: 6602418274. eLibrary SPIN: 3163-4119
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