Prevention of progression of chronic heart failure with preserved ejection fraction: Estimation of the correlation between NT-proBNP levels and clinical and functional characteristics during control of the disease
Abstract. A promising direction of modern medicine development is the implementation of point-of-care diagnostic methods, which allows to optimize primary and secondary prevention, as well as treatment strategies for patients with chronic non-infectious diseases. The aim: to evaluate the correlation between N-terminal propeptide of B-type natriuretic hormone (NT-proBNP) level and clinical and functional parameters in patients with chronic heart failure with preserved ejection fraction (CHFpEF) to optimize secondary prevention strategies. Material and methods. Current research work was performed from November 1, 2022, to December 1, 2024, at Novosibirsk Regional Clinical Hospital for War Veterans No. 3. The study included 149 individuals (96 male and 53 female) with a history of myocardial infarction and CHFpEF. Their clinical and functional characteristics were assessed, and NT-proBNP concentrations in the blood were measured using the NT-proBNP K rapid test. Results. A statistically significant correlation was found between NT-proBNP level measured using the rapid test and left vpentricular ejection fraction (r = -0.335; p < 0.01), 6-minute walking test results (r = -0.230, p < 0.01), RSCS indexes (r = 0.650, p < 0.01), as well as with main clinical characteristics of CHF – pulmonary rales (r = 0.626, p < 0.01), orthopnea (r = 0.516, p < 0.01), edema (r = 0.465, p < 0.01), shortness of breath (r = 0.396, p < 0.01), coughing (r = 0.369, p < 0.01). Conclusion. Regular NT-proBNP monitoring serves as a secondary prevention tool, enabling preclinical diagnosis of cardiac dysfunction and timely treatment. A rapid, quantitative method for determining this biomarker has significant diagnostic potential in internal medicine for patients with CHFpEF.Gerasimenko O.N., Zhamalov L.M., Nikolaev K.Yu., Zimina Yu.D., Tolmacheva A.A.
Keywords
chronic heart failure
diagnosis of chronic heart failure
prevention of chronic heart failure
NT-proBNP rapid measurement method
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About the Authors
Oksana N. Gerasimenko, MD, Dr. Sci. (Medicine), professor, head of the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630091, Novosibirsk, 52 Krasny Avenue.E-mail: profgerasimenko@inbox.ru
ORCID: https://orcid.org/0000-0002-9742-0479
Linar M. Zhamalov, MD, physician-methodologist of the Department of monitoring the organization of medical care of the Center for Organizational and Methodological Management and Analysis of the Quality of Medical Care in the Regions, assistant at the Department of public health and healthcare organization of the Institute of Professional Education and Accreditation, National Medical Research Center of Therapy and Preventive Medicine of the Ministry of Healthcare of Russia; assistant at the Department of internal medicine and family medicine, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 101990, Moscow, 10/3 Petroverigsky Lane.
E-mail: L.m.zhamalov@mail.ru
Konstantin Yu. Nikolaev, MD, Dr. Sci. (Medicine), professor, chief researcher with the acting title of head of the Department of emergency therapy, Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center, Institute of Cytology and Genetics of Siberian branch of the Russian Academy of Sciences. Address: 630089, Novosibirsk, 175/1 B. Bogatkova St.
E-mail: nikolaevky@yandex.ru
ORCID: https://orcid.org/0000-0003-4601-6203
Yulia D. Zimina, MD, postgraduate student of the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630091, Novosibirsk, 52 Krasny Avenue.
E-mail: yulya_tx@mail.ru
ORCID: https://orcid.org/0000-0001-9027-6884
Anastasia A. Tolmacheva, MD, PhD (Medicine), assistant at the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine, Novosibirsk State Medical University of the Ministry of Healthcare of Russia. Address: 630091, Novosibirsk, 52 Krasny Avenue.
E-mail: tolmacheva_nastena@mail.ru
ORCID: https://orcid.org/0000-0003-1687-4100
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