Ideal marker of renal glomerular filtration rate: Myth or reality?

1. Institute for Health Metrics and Evaluation. GBD Results. GBD 2021. 2025, University of Washington. URL: https://vizhub.healthdata.org/gbd-results/?params=gbd-api-2021-permalink/dbb9f2e403d43b898887a99ec50ec6ff (date of access – 10.07.2025).

2. World Health Organization. World health statistics 2024: Monitoring health for the SDGs, Sustainable Development Goals. 2024; 96 pp. URL: https://books.google.ru/books?id=4acOEQAAQBAJ (date of access – 10.07.2025). ISBN: 9240094709, 9789240094703.

3. Li X, Lindholm B. Cardiovascular risk prediction in chronic kidney disease. Am J Nephrol. 2022;53(10):730–39.

PMID: 36481730. https://doi.org/10.1159/000528560

4. Клинические рекомендации. Хроническая болезнь почек (ХБП). Национальная ассоциация нефрологов. Рубрикатор клинических рекомендаций Минздрава России. 2024. ID: 469_3. Доступ: https://cr.minzdrav.gov.ru/preview-cr/469_3 (дата обращения – 10.07.2025) (Clinical guidelines. Chronic kidney disease (CKD). National Association of Nephrologists. Rubricator of clinical guidelines of the Ministry of Healthcare of Russia. 2024. ID: 469_3. URL: https://cr.minzdrav.gov.ru/preview-cr/469_3 (date of access – 10.07.2025) (In Russ.)).

5. Волкова И.А., Савина М.И. Особенности методов оценки скорости клубочковой фильтрации. Медицинский алфавит. 2019;3(22):43–47. (Volkova IA, Savina MI. Features of methods of glomerular filtration rate estimation. Meditsinskiy alfavit = Medical Alphabet. 2019;3(22):43–47 (In Russ.)).

EDN: SRJRGX. https://doi.org/10.33667/2078-5631-2019-3-22(397)-43-47

6. Каюков И.Г., Галкина О.В., Тимшина Е.И., Зубина И.М., Михеева А.Ю., Бердичевский Г.М. Креатинин в современной оценке функционального состояния почек (обзор литературы и собственные данные). Нефрология. 2020;24(4):21–36. (Kayukov IG, Galkina OV, Timshina EI, Zubina IM, Miheeva AYu, Berdichevsky GM. Creatinin in the modern evaluation of the kidneys functional condition (literature review and own data). Nefrologiya = Nephrology (Saint Petersburg). 2020;24(4):21–36 (In Russ.)).

EDN: QNVIIX. https://doi.org/10.36485/1561-6274-2020-24-4-21-36

7. Ferguson MA, Waikar SS. Established and emerging markers of kidney function. Clin Chem. 2012;58(4):680–89.

PMID: 22311920. PMCID: PMC5136473. https://doi.org/10.1373/clinchem.2011.167494

8. Вельков В.В., Резникова О.И. Современная лабораторная диагностика ренальных патологий: от ранних стадий до острой почечной недостаточности: методическое пособие. М.: ЗАО «Диакон». 2010; 9 с. (Velkov VV, Reznikova OI. Modern laboratory diagnostics of renal pathologies: From early stages to acute renal failure: A methodical guide. Moscow: Diakon, 2010; 9 pp. (In Russ.)).

9. Spencer S, Desborough R, Bhandari S. Should cystatin C eGFR become routine clinical practice? Biomolecules. 2023;13(7):1075.

PMID: 37509111. PMCID: PMC10377068. https://doi.org/10.3390/biom13071075

10. Мирошников М.В., Ковалева М.А., Султанова К.Т. Обзор методов определения скорости клубочковой фильтрации в доклинических исследованиях. Лабораторные животные для научных исследований. 2024;(3):66–77. (Miroshnikov MV, Kovaleva MA, Sultanova KT. Review of methods for determining the glomerular filtration rate in preclinical studies. Laboratornye zhivotnye dlya nauchnykh issledovaniy = Laboratory Animals for Science. 2024;(3):66–77 (In Russ.)).

EDN: IMJIQA. https://doi.org/10.57034/2618723X-2024-03-06

11. Inker LA, Titan S. Measurement and estimation of GFR for use in clinical practice: Core Curriculum 2021. Am J Kidney Dis. 2021;78(5):736–49.

PMID: 34518032. https://doi.org/10.1053/j.ajkd.2021.04.016

12. Xin C, Xie J, Fan H, Sun X, Shi B. Association between serum cystatin C and thyroid diseases: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2021;12:766516.

PMID: 34867811. PMCID: PMC8639734. https://doi.org/10.3389/fendo.2021.766516

13. Liang S, Shi M, Bai Y, Deng Y, Fang M, Li J et al. The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: A propensity-matched cohort study. BMC Nephrol. 2020;21(1):519.

PMID: 33246435. PMCID: PMC7694927. https://doi.org/10.1186/s12882-020-02165-1

14. Клинические практические рекомендации KDIGO 2012 по диагностике и лечению хронической болезни почек. Нефрология и диализ. 2017;19(1):22–206. (KGIGO 2012 Clinical practice guideline for the evaluation and management of chronic kidney disease. Nefrologiya i dializ = Nephrology and Dialysis. 2017;19(1):22–206 (In Russ.)).

EDN: YKVZBX. https://doi.org/10.28996/1680-4422-2017-1-22-206

15. Argyropoulos CP, Chen SS, Ng Y-H, Roumelioti M-E, Shaffi K, Singh PP, Tzamaloukas AH. Re-discovering beta-2 microglobulin as a biomarker across the spectrum of kidney diseases. Front Med (Lausanne). 2017;4:73.

PMID: 28664159. PMCID: PMC5471312. https://doi.org/10.3389/fmed.2017.00073

16. Муркамилов И.Т., Айтбаев К.А., Муркамилова Ж.А., Фомин В.В., Юсупов Ф.А. Бета-2-микроглобулин как биомаркер при хронической болезни почек. The Scientific Heritage. 2021;59-2(59):45–55. (Murkamilov IT, Aitbaev KA, Murkamilova ZhA, Fomin VV, Yusupov FA. Beta-2-microglobulin as a biomarker in chronic kidney disease. The Scientific Heritage. 2021;59-2(59):45–55 (In Russ.)).

EDN: UBYKCQ. https://doi.org/10.24412/9215-0365-2021-59-2-45-55

17. Казаченко А.В., Войтко Д.А., Просянников М.Ю., Константинова О.В., Анохин Н.В, Аполихин О.И., Каприн А.Д. Современные маркеры определения функциональной способности почек в урологической практике. Экспериментальная и клиническая урология. 2023;16(1):174–187. (Kazachenko AV, Voytko DA, Prosyannikov MYu, Konstantinova OV, Anokhin NV, Apolikhin OI, Kaprin AD. Modern markers for determining the functional ability of the kidneys in urological practice. Eksperimental’naya i klinicheskaya urologiya = Experimental and Clinical Urology. 2023;16(1):174–187 (In Russ.)).

https://doi.org/10.29188/2222-8543-2023-16-1-174-187

18. Foster MC, Coresh J, Hsu C-Y, Xie D, Levey AS, Nelson RG et al.; CKD Biomarker Consortium and the CRIC Study Investigators. Serum β-trace protein and β2-microglobulin as predictors of ESRD, mortality, and cardiovascular disease in adults with CKD in the chronic renal insufficiency cohort (CRIC) study. Am J Kidney Dis. 2016;68(1):68–76.

PMID: 26948990. PMCID: PMC4921300. https://doi.org/10.1053/j.ajkd.2016.01.015

19. Inker LA, Couture SJ, Tighiouart H, Abraham AG, Beck GJ, Feldman HI et al.; CKD-EPI GFR Collaborators. A new panel-estimated GFR, including β2-microglobulin and β-trace protein and not including race, developed in a diverse population. Am J Kidney Dis. 2021;77(5):673–683.e1.

PMID: 33301877. PMCID: PMC8102017. https://doi.org/10.1053/j.ajkd.2020.11.005

20. Uemura O, Ishikura K, Kamei K, Hamada R, Yamamoto M, Gotoh Y et al. Comparison of inulin clearance with 2-h creatinine clearance in Japanese pediatric patients with renal disease: Open-label phase 3 study of inulin. Clin Exp Nephrol. 2022;26(2):132–39.

PMID: 34562149. PMCID: PMC8770449. https://doi.org/10.1007/s10157-021-02133-5

21. Ebert N, Schaeffner E, Seegmiller JC, van Londen M, Bökenkamp A, Cavalier E et al.; European Federation of Clinical Chemistry and Laboratory Medicine Task Group on Chronic Kidney Disease (EFLM TG-CKD). Iohexol plasma clearance measurement proto-col standardization for adults: A consensus paper of the European Kidney Function Consortium. Kidney Int. 2024;106(4):583–96.

PMID: 39097002. https://doi.org/10.1016/j.kint.2024.06.029

22. Ebert N, Bevc S, Bökenkamp A, Gaillard F, Hornum M, Jager KJ et al. Assessment of kidney function: Clinical indications for measured GFR. Clin Kidney J. 2021;14(8):1861–70.

PMID: 34345408. PMCID: PMC8323140. https://doi.org/10.1093/ckj/sfab042

23. Cheng W, Zhao F, Tang C-Y, Li X-W, Luo M, Duan S-B. Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model. Arch Toxicol. 2018;92(7):2245–57.

PMID: 29860548. https://doi.org/10.1007/s00204-018-2225-9

24. Good Clinical Practice Network. Клиническое испытание NCT01545531. Двухточечное измерение скорости клубочковой фильтрации по исчезновению йогексола в плазме. Доступ: https://ichgcp.net/ru/clinical-trials-registry/NCT01545531 (дата обращения – 10.07.2025). (Good Clinical Practice Network. Clinical Trial NCT01545531. Two-Point Measurement of Glomerular Filtration Rate by Iohexol Plasma Disappearance. URL: https://ichgcp.net/ru/clinical-trials-registry/NCT01545531 (date of access – 10.07.2025) (In Russ.)).

25. Utiel FJB, Navarro AMR, de la Rosa RE, Soto JAB. Comparison of MDRD and the old CKD-EPI equations with the new CKD-EPI equations in kidney transplant patients when glomerular filtration rate is measured with 51Cr-EDTA. Nefrologia (Engl Ed). 2020;40(1):53–64.

PMID: 31843209. https://doi.org/10.1016/j.nefro.2019.07.006

26. Чехонацкая М.Л., Аверьянов А.П., Утц И.А., Великанова М.Г., Бобылев Д.А., Chekhonatsky I.A. Лучевые методы оценки функции почек у детей. Саратовский научно-медицинский журнал. 2018;14(3):385–388. (Chekhonatskaya ML, Averyanov AP, Utz IA, Velikanova MG, Bobylev DA, Chekhonatsky IA. Saratovskiy nauchno-meditsinskiy zhurnal = Saratov Journal of Medical Scientific Research. 2018;14(3):385–388 (In Russ.)). EDN: YZNJCH.

27. Смирнов И.Е., Комарова Н.Л., Герасимова Н.П., Видюков В.И. Новая технология радионуклидной оценки функциональной активности почечной ткани у детей. Российский педиатрический журнал. 2014;17(5):30–33. (Smirnov IE, Komarova NL, Gerasimova NP, Vidyukov VI. New radionuclide technology for the assessment of the functional activity of renal tissue in children. Rossiiskii pediatricheskii zhurnal = Russian Pediatric Journal. 2014;17(5):30–33 (In Russ.)). EDN: TANOHL.

28. Molitoris BA, Reilly ES. Quantifying glomerular filtration rates in acute kidney injury: A re-quirement for translational success. Semin Nephrol. 2016;36(1):31–41.

PMID: 27085733. PMCID: PMC4834456. https://doi.org/10.1016/j.semnephrol.2016.01.008

29. Perez ZH, Weinfurter S, Gretz N. Transcutaneous assessment of renal function in conscious rodents. J Vis Exp. 2016;(109):e53767.

PMID: 27078159. PMCID: PMC4841314. https://doi.org/10.3791/53767

30. Fanous MS, Afolabi JM, Michael OS, Falayi OO, Iwhiwhu SA, Adebiyi A. Transdermal measurement of glomerular filtration rate in mechanically ventilated piglets. J Vis Exp. 2022;(187):10.3791/64413.

PMID: 36190295. PMCID: PMC9835146. https://doi.org/10.3791/64413

31. Scarfe L, Schock-Kusch D, Ressel L, Friedemann J, Shulhevich Y, Murray P et al. Transdermal measurement of glomerular filtration rate in mice. J Vis Exp. 2018;(140):58520.

PMID: 30394397. PMCID: PMC6235579. https://doi.org/10.3791/58520

32. Steinbach S, Krolop N, Strommer S, Herrera-Pérez Z, Geraci S, Friedemann J et al. A pilot study to assess the feasibility of transcutaneous glomerular filtration rate measurement using fluorescence-labelled sinistrin in dogs and cats. PLoS One. 2014;9(11):e111734.

PMID: 25423195. PMCID: PMC4244090. https://doi.org/10.1371/journal.pone.0111734

33. Molitoris BA. Rethinking CKD evaluation: Should we be quantifying basal or stimulated GFR to maximize precision and sensitivity? Am J Kidney Dis. 2017;69(5):675–83.

PMID: 28223001. PMCID: PMC5403623. https://doi.org/10.1053/j.ajkd.2016.11.028

34. Charlton JR, Tan W, Daouk G, Teot L, Rosen S, Bennett KM et al. Beyond the tubule: Pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease. Am J Physiol Renal Physiol. 2020;319(6):F988–F999.

PMID: 33103447. PMCID: PMC7792689. https://doi.org/10.1152/ajprenal.00295.2020

35. Zhang J, Wei J, Jiang S, Xu L, Wang L, Cheng F et al. Macula densa SGLT1-NOS1-tubuloglomerular feedback pathway, a new mechanism for glomerular hyperfiltration during hyperglycemia. J Am Soc Nephrol. 2019;30(4):578–93.

PMID: 30867247. PMCID: PMC6442354. https://doi.org/10.1681/asn.2018080844

36. Carlström M, Carvalho LRRA, Guimaraes D, Boeder A, Schiffer TA. Di-methyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase. Redox Biol. 2024;69:102984.

PMID: 38061207. PMCID: PMC10749277. https://doi.org/10.1016/j.redox.2023.102984

37. Pottel H, Delanaye P, Cavalier E. Exploring renal function assessment: Creatinine, cystatin C, and estimated glomerular filtration rate focused on the European Kidney Function Consortium Equation. Ann Lab Med. 2024;44(2):135–43.

PMID: 37909162. PMCID: PMC10628758. https://doi.org/10.3343/alm.2023.0237

38. Jaques DA, Davenport A. Serum β2-microglobulin as a predictor of residual kidney function in peritoneal dialysis patients. J Nephrol. 2021;34(2):473–81.

PMID: 33270187. PMCID: PMC8036192. https://doi.org/10.1007/s40620-020-00906-x

39. White CA, Ghazan-Shahi S, Adams MA. β-Trace protein: A marker of GFR and other biological pathways. Am J Kidney Dis. 2015;65(1):131–46.

PMID: 25446025. https://doi.org/10.1053/j.ajkd.2014.06.038

40. Государственный реестр лекарственных средств Минздрава России. Инструкции по медицинскому применению лекарственных препаратов с МНН йодиксанол. Доступ: https://grls.rosminzdrav.ru/GRLS.aspx?RegNumber=&MnnR=Йодиксанол&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&regtype=1%2c6&pageSize=10&token=496ef1aa-5986-4c9e-82c6-1ffb9bf1a206&order=Registered&orderType=desc&pageNum=1 (дата обращения – 10.07.2025). (State Register of Medicines of the Ministry of Healthcare of Russia. Instructions for medical use of drugs with INN iodixanol. URL: https://grls.rosminzdrav.ru/GRLS.aspx?RegNumber=&MnnR=Йодиксанол&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&regtype=1%2c6&pageSize=10&token=496ef1aa-5986-4c9e-82c6-1ffb9bf1a206&order=Registered&orderType=desc&pageNum=1 (date of access – 10.07.2025) (In Russ.)).