Mönckeberg’s disease: A case report
Abstract. Mönckeberg’s disease is a systemic medial calcification of muscular arteries with calcification of the media while intima remains intact, which distinguishes it from atherosclerosis. This article presents the case of a 78-year-old female patient with widespread calcification of the coronary arteries, valves, aorta, and peripheral arteries of the upper and lower extremities. Coronary angiography revealed a multivessel lesion with severe calcification and a normal lipid profile, which could not be recanalized even with a rotablator. Echocardiography revealed severe mitral and aortic regurgitation with severe valve calcification, which made implantation of the MitraClip device not possible. Introduced clinical observation suggests that Mönckeberg’s disease should be considered as a possible cause in patients with widespread vascular calcification that does not fit the classic picture of atherosclerosis. However, due to the lack of specific markers, its diagnosis requires a comprehensive evaluation.S.A. Boldueva, E.G. Bykova, D.S. Evdokimov, I.N. Kochanov, V.A. Kovalev, K.A. Gladysheva, A.E. Steblev
Keywords
Mönckeberg’s disease
atrial fibrillation
valve pathology
coronary artery calcification
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About the Authors
Svetlana A. Boldueva, MD, Dr. Sci. (Medicine), professor, head of the Department of faculty therapy, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation.E-mail: svetlanaboldueva@mail.ru
ORCID: https://orcid.org/0000-0002-1898-084X. Scopus ID: 6506877971. eLibrary SPIN: 3716-3375
Elena G. Bykova, MD, PhD (Medicine), associate professor of the Department of faculty therapy, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation.
E-mail: bykovaelenag@mail.ru
ORCID: https://orcid.org/0000-0001-9902-2338. eLibrary SPIN: 9315-9340
Dmitry S. Evdokimov, MD, PhD (Medicine), assistant at the Department of faculty therapy, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation.
E-mail: kasabian244@gmail.com
ORCID: https://orcid.org/0000-0002-3107-1691. Scopus ID: 57216438647. eLibrary SPIN: 5944-6425
Igor N. Kochanov, MD, PhD (Medicine), head of the Department of endovascular diagnostics and treatment, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation.
E-mail: igor.kochanov@szgmu.ru
ORCID: https://orcid.org/0000-0002-3499-1792. eLibrary SPIN: 5944-6425
Vadim A. Kovalev, MD, physician of functional diagnostics, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation.
E-mail: Vadim.Kovalev@szgmu.ru
Kristina A. Gladysheva, MD, first-year clinical resident in cardiology of the Department of faculty therapy, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation.
E-mail: kristinka.gl@mail.ru
ORCID: https://orcid.org/0009-0001-2262-2770
Artem E. Steblev, fourth-year student, I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation.
E-mail: Steblevartem594@gmail.com
ORCID: https://orcid.org/0009-0009-0861-7172. eLibrary SPIN: 5639-6734
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