Possibilities of multi-vector therapy with N-acetylcysteine in the treatment of acute bronchitis
Abstract. Acute bronchitis (AB) is an acute inflammation of the bronchial tissue, which often occurs in association with upper respiratory tract infections in the absence of chronic bronchopulmonary diseases. Etiologic agent of AB is rarely determined, but in most cases it is caused by viruses and much less often by bacteria. If the patient has chronic bronchopulmonary pathology (for example, bronchial asthma, chronic bronchitis, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis), acute inflammation of the tracheobronchial tree is an exacerbation of the chronic disease, and not AB. It is fundamentally important to distinguish between these clinical situations due to the difference in approaches to their therapy and possible outcomes. In the treatment of OB, symptomatic therapy is used.most often. In that case leading role is played by mucoactive drugs, although in some cases it may be necessary to prescribe other groups of medicines – antibiotics, inhaled glucocorticosteroids, antitussives. The aim of the article: to highlight the possibilities of multi-vector therapy of this disease by means of N-acetylcysteine use.Makarova M.A., Belevsky A.S., Krasovsky S.A.
Keywords
productive cough
acute bronchitis
N-acetylcysteine
biofilms
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About the Authors
Marina A. Makarova, MD, PhD (Medicine), associate professor of the Department of pulmonology, institute of continuous education and professional development, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia (Pirogov University), researcher at the Department of intensive care and respiratory failure, Research Institute of Pulmonology of Federal Medical and Biological Agency of Russia, pulmonologist at the Department of respiratory medicine, S.S. Yudin City Clinical Hospital of the Department of Healthcare of Moscow. Address: 117513, Moscow, 1/6 Ostrovityanova St.E-mail: mma123@list.ru
ORCID: https://orcid.org/0000-0003-4913-087X. eLibrary SPIN: 7153-0940
Andrey S. Belevsky, MD, Dr. Sci. (Medicine), professor, president of the Russian Respiratory Society, chief external expert – pulmonologist of the Department of Healthcare of the Government of Moscow, head of the Department of pulmonology of the Institute of continuous education and professional development, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia (Pirogov University). Address: 117513, Moscow, 1/6 Ostrovityanova St.
E-mail: pulmobas@yandex.ru
ORCID: https://orcid.org/0000-0001-6050-724X. eLibrary SPIN: 7313-8885
Stanislav A. Krasovsky, MD, PhD (Medicine), senior researcher at the Department of cystic fibrosis, Research Institute of Pulmonology of Federal Medical and Biological Agency of Russia, leading researcher at Scientific and Clinical Department, Academician N.P. Bochkov Medical and Genetic Research Center the Ministry of Science and Higher Education of the Russian Federation. Address: 115682, Moscow, 28/10 Orekhovy Boulevard.
E-mail: sa_krasovsky@mail.ru
ORCID: https://orcid.org/0000-0001-9642-0947. eLibrary SPIN: 3385-6489
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