Rifaximine in therapy of gastrointestinal tract diseases: From the history of its creation to modern recommendations
Abstract. Rifaximin is a broad-spectrum antibiotic from the rifamycin group, which has minimal systemic absorption and implements its effect mainly in the intestinal lumen. It is actively used in the therapy of gastrointestinal tract diseases of various origins, including acute intestinal infections, bacterial overgrowth syndrome, traveler’s diarrhea and hepatic encephalopathy. The article presents current data on the mechanism of action, pharmacokinetics and pharmacodynamics of rifaximin, substantiates its advantages over systemic antibacterial medicines, and discusses the aspects concerning risks of developing antibiotic resistance with long-term use. Particular attention is paid to the results of clinical studies confirming the efficacy and safety of the medicine.Ketova G.G., Shamina O.M., Mironov I.L.
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References
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About the Authors
Galina G. Ketova, MD, Dr. Sci. (Medicine), professor, professor of the Department of outpatient therapy and clinical pharmacology, South Ural State Medical University of the Ministry of Healthcare of Russia. Address: 454092, Chelyabinsk, 64 Vorovskogo St.E-mail: Galina_Ketova@mail.ru
ORCID: https://orcid.org/0000-0001-5087-9525. Scopus ID: 57192404114. eLibrary SPIN: 8522-4038
Olga M. Shamina, MD, clinical pharmacologist of the Clinic, assistant at the Department of outpatient therapy and clinical pharmacology, South Ural State Medical University of the Ministry of Healthcare of Russia. Address: 454092, Chelyabinsk, 64 Vorovskogo St.
E-mail: olmashamina@gmail.com
ORCID: https://orcid.org/0000-0001-9421-3020. eLibrary SPIN: 5526-5681
Igor L. Mironov, MD, PhD (Medicine), associate professor of the Department of infectious diseases, South Ural State Medical University of the Ministry of Healthcare of Russia. Address: 454092, Chelyabinsk, 64 Vorovskogo St.
E-mail: igmir@yandex.ru
ORCID: https://orcid.org/0009-0007-9863-5037. eLibrary SPIN: 6294-3778