Predictors of anemia development in long-lasting post-COVID syndrome
Abstract. Prevalence and significance of anemia in COVID-19, especially in post-COVID period, have not been studied sufficiently. Data on the frequency and prognostic role of this condition in patients in the post-COVID period are contradictory. One of the promising directions in cardiology and therapy is the study of anemia development predictors in patients with shortness of breath who have had a novel coronavirus infection (NCVI). The aim: to determine predictors of anemia development in patients with shortness of breath in long-lasting post-COVID syndrome. Material and methods. From March 2020 to August 2023, 878 patients visited a pulmonologist in outpatient clinic for dyspnea ≥ 3 months after NCVI. 205 persons of them who met the inclusion criteria and had no exclusion criteria were selected for the study. Anemia was registered in 35 (17.1%) of them (Group 1), the remaining 170 (82.9%) participants did not have this condition (Group 2). Results. Patients who underwent NCVI in the group with hemoglobin level of ≤ 129 g/l in males and ≤ 119 g/l in females had a statistically significantly lower level of serum iron in the limit of normal range. A strong direct correlation was found between hemoglobin and serum iron (r = 0.479, p < 0.05). Patients with anemia were statistically more likely to have in anamnesis NCVI with pneumonia, NCVI with pneumonia and hospitalization, NCVI with intensive care unit stay, as well as a prolonged clinical course of NCVI of ≥ 12 weeks. In addition, in the 1st group of the study, a statistically significantly lower glomerular filtration rate in the range of 45–59 ml / min. / 1.73 m2 was recorded. Conclusion. The development of anemia was associated with more severe forms of previous NCVI complicated by pneumonia with hospitalization. Anemia more often developed in patients over 60 years old, it was accompanied by metabolic disorders and concomitant pathology.Koziolova N.A., Chernyavina A.I., Masalkina O.V., Sosnin D.Yu.
Keywords
shortness of breath
anemia
post-COVID syndrome
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About the Authors
Natalya A. Koziolova, MD, Dr. Sci. (Medicine), professor, head of the Department of internal medicine propaedeutics No. 2, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614000, Perm, 26 Petropavlovskaya St.E-mail: nakoziolova@mail.ru
ORCID: https://orcid.org/0000-0001-7003-5186. eLibrary SPIN: 1044-0503
Anna I. Chernyavina, MD, Dr. Sci. (Medicine), associate professor of the Department of internal medicine propaedeutics No. 2, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614000, Perm, 26 Petropavlovskaya St.
E-mail: anna_chernyavina@list.ru
ORCID: https://orcid.org/0000-0002-0051-6694. eLibrary SPIN: 2387-6781
Olga V. Masalkina, MD, PhD (Medicine), associate professor of the Department of internal medicine propaedeutics No. 2, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614000, Perm, 26 Petropavlovskaya St.
E-mail: omasalkina@mail.ru
ORCID: https://orcid.org/0009-0006-3364-0591. eLibrary SPIN: 4394-5330
Dmitry Yu. Sosnin, MD, Dr. Sci. (Medicine), professor of the Department of faculty therapy No. 2, occupational pathology and clinical laboratory diagnostics, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614000, Perm, 26 Petropavlovskaya St.
E-mail: sosnin_dm@mail.ru
ORCID: https://orcid.org/0000-0002-1232-8826. eLibrary SPIN: 4204-6796
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