Estimation of the spectrum and severity of COVID-19-associated metabolic changes in patients with non-alcoholic fatty liver disease
Abstract. COVID-19 pandemic has posed new questions for physicians and researchers regarding the management of patients with non-alcoholic fatty liver disease (NAFLD). In addition to direct cytopathic effect, SARS-CoV-2 can induce a cascade of metabolic disorders, including dyslipidemia.Zhuk K.S., Tarlovskaya E.I., Vlasova T.V.
The aim: to perform a comprehensive estimation of the spectrum and severity of metabolic changes associated with COVID-19 in patients with NAFLD in the post-COVID period.
Material and methods. Retrospective cohort study included 73 patients with NAFLD, 22 of whom had COVID-19 from March 2020 to February 2021. The participants were analyzed for parameters of lipid spectrum, glycemic profile, inflammatory markers, and liver function.
Results. In patients who had COVID-19, comparatively with patients who did not have it, a statistically significant increase in the level of total cholesterol, low-density lipoprotein cholesterol, triglycerides, cholesterol not associated with high-density lipoproteins, glucose, glycated hemoglobin, C-reactive protein, and ferritin, as well as a decrease in the level of high-density lipoprotein cholesterol relatively to their baseline levels in 2019 was found.
Conclusion. COVID-19 in patients with NAFLD is associated with a high frequency and a wide range of metabolic disorders that potentially affect the progression of liver damage. Obtained data dictate the need for careful monitoring of metabolic parameters and optimization of therapeutic approaches in this group of patients.
Keywords
COVID-19
liver disease
dyslipidemia
metabolic disorders
systemic inflammation
lipid spectrum
non-alcoholic fatty liver disease
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About the Authors
Ksenia S. Zhuk, MD, assistant at the Department of therapy and cardiology, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10 Minina i Pozharskogo Sq.E-mail: zhukks@rambler.ru
ORCID: https://orcid.org/0009-0007-7413-5046. eLibrary SPIN: 4726-3959
Ekaterina I. Tarlovskaya, MD, Dr. Sci. (Medicine), professor, head of the Department of therapy and cardiology, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10 Minina i Pozharskogo Sq.
E-mail: etarlovskaya@mail.ru
ORCID: https://orcid.org/0000-0002-9659-7010. Scopus ID: 16305274900. eLibrary SPIN: 5007-4647
Tatyana V. Vlasova, MD, PhD (Medicine), associate professor of the Department of therapy of the Faculty of continuous professional education, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10 Minina i Pozharskogo Sq.
E-mail: taniavlasova@yandex.ru
ORCID: https://orcid.org/0009-0005-5856-0208. Scopus ID: 57217079352. eLibrary SPIN: 9034-6670
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