Heparin-induced thrombocytopenia due to low-molecular weight heparin in female patient after aortic valve replacement with a mechanical prosthesis
Abstract. Heparin-induced thrombocytopenia (HIT) is a serious and potentially life-threatening complication of heparin therapy. In patients who received unfractionated heparin as anticoagulant therapy for ≥ 4 days, the incidence of HIT varies from 0.2 to 5%. Although the risk of HIT developing with low molecular weight heparin (LMWH) injection is 10 times lower, such cases still occur in clinical practice. Due to insufficient awareness of physicians about such complication of heparin therapy and the lack of necessary laboratory tests, the diagnosis of HIT is often delayed. The article presents a clinical case of HIT during LMWH therapy in a 65-year-old female patient after mechanical aortic valve replacement under artificial blood circulation, complicated by arterial and venous thromboses, including hemodynamically significant pulmonary embolism, which required thrombolytic therapy, as well as occlusive thrombosis of the femoral-popliteal-tibial segment of the arteries of the right lower limb, which necessitated surgical recanalization.Tatarintseva Z.G., Palshkova A.D., Sinelnikova M.G., Kosmacheva E.D.
Keywords
heparin-induced thrombocytopenia
anticoagulant therapy
mechanical aortic valve replacement
low molecular weight heparin
pulmonary embolism
References
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About the Authors
Zoya G. Tatarintseva, MD, PhD (Medicone), head of the Department of cardiology, Professor S.V. Ochapovsky Research Institute – Regional Clinical Hospital No. 1, assistant at the Department of cardiac surgery and cardiology of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350086, Krasnodar, 167 Pervogo Maya St.E-mail: z.tatarintseva@list.ru
ORCID: https://orcid.org/0000-0002-3868-8061. Scopus ID: 57204855465. eLibrary SPIN: 9613-3479
Arina D. Palshkova, resident of the Department of cardiac surgery and cardiology of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350063, Krasnodar, 4 Mitrofana Sedina St.
E-mail: arinapalshkova11@mail.ru
ORCID: https://orcid.org/0009-0007-7949-649Х
Maria G. Sinelnikova, resident of the Department of cardiac surgery and cardiology of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350063, Krasnodar, 4 Mitrofana Sedina St.
E-mail: missosin@yandex.ru
ORCID: https://orcid.org/0009-0004-6277-1502
Elena D. Kosmacheva, MD, Dr. Sci. (Medicine), professor, deputy chief physician for medical affairs of Professor S.V. Ochapovsky Research Institute – Regional Clinical Hospital No. 1, head of the Department of therapy No. 1 of the Faculty of advanced training and professional retraining of specialists, Kuban State Medical University of the Ministry of Healthcare of Russia. Address: 350086, Krasnodar, 167 Pervogo Maya St.
E-mail: kosmachova_h@mail.ru
ORCID: https://orcid.org/0000-0001-5690-2482. Scopus ID: 57219783567
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