Asthenia: Actual points of diagnostics and correction
Abstract. In modern medical practice, asthenic syndrome (AS) as a multifactorial pathological condition occupies one of the leading places. The prevalence of asthenia in general somatic practice varies from 45 to 90%. AS is characterized by a variety of non-specific clinical manifestations, while its dominant symptoms include general weakness and fatigue caused by energy deficiency at the cellular level, the development of which is based on such pathological processes as inflammation, oxidative stress and mitochondrial dysfunction. Various stressors, acute and chronic diseases of internal organs, including infectious ones, can act as etiological factors of asthenia. In practical medicine, special attention should be paid to secondary asthenia, which develops as a result of the underlying disease, worsens the course of the latter and has an unfavorable prognostic value. Timely diagnosis of AS and its correction make it possible to stop the manifestations of asthenia, improve the quality of life and prognosis of patients.Ebzeeva E.Yu., Ostroumova O.D., Krotkova I.F., Doldo N.M.
Keywords
asthenia
weakness
energy deficiency
oxidative stress
vegetative dysfunction
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About the Authors
Elizaveta Yu. Ebzeeva, MD, PhD (Medicine), associate professor of the Department of therapy and polymorbid pathology named after academician M.S. Vovsi, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia. Address: 125993, Moscow, 2/1 bld. 1 Barrikadnaya St.E-mail: veta-veta67@mail.ru
ORCID: https://orcid.org/0000-0001-6573-4169
Olga D. Ostroumova, MD, Dr. Sci. (Medicine), professor, head of the Department of therapy and polymorbid pathology named after academician M.S. Vovsi, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia, professor of the Department of clinical pharmacology and propaedeutics of internal diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 125993, Moscow, 2/1 bld.1 Barrikadnaya St.
E-mail: ostroumova.olga@mail.ru
ORCID: https://orcid.org/0000-0002- 0795-8225
Irina F. Krotkova, MD, PhD (Medicine), associate professor of the Department of therapy and polymorbid pathology named after academician M.S. Vovsi, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia. Address: 125993, Moscow, 2/1 bld. 1 Barrikadnaya St.
E-mail: krotira@mail.ru
ORCID: https://orcid.org/0000-0002-9597-1648
Nikolay M. Doldo, MD, head of the Department of therapy, “RZhD-Medicine” Central Clinical Hospital. Address: 125315, Moscow, 84 Volokolamskoe Highway.
E-mail: kolj.spb@mail.ru
ORCID: https://orcid.org/0000-0002-0821-7373
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