The role of intestinal microbiocenosis in human iron metabolism
Abstract. Intestinal dysbiosis is considered as an underestimated factor in iron deficiency anemia (IDA) pathogenesis. Of particular interest is the contribution of bacterial genus Desulfovibrio spp. and its metabolite hydrogen sulfide to impaired iron absorption and distribution. The aim: to summarize current data on the impact of dysbiosis on iron homeostasis. Publications were selected from international and Russian databases (PubMed/MEDLINE, Scopus, WoS, eLIBRARY, CyberLeninka) to include in the review original studies, systematic reviews, meta-analyses, and clinical guidelines. According to the results of relevant scientific literature analysis, iron deficiency and oral Fe²+ salts cause an imbalance in the microbiota with an increased growth of Proteobacteria (including Enterobacteriaceae) while decreasing the number of butyrate producers. Desulfovibrio spp. compete with host organism for iron and produce hydrogen sulfide, which damages the intestinal epithelium and can directly suppress ferroportin synthesis, reducing iron export from enterocytes. Thus, dysbiosis is a significant factor of IDA persistence. Further study of this problem and aspects of complex therapy for IDA, such as dysbiosis correction, choice of parenteral iron administration, and personalized monitoring of hepcidin levels, is necessary.Bityumina L.A., Koroleva I.B., Vinokurov M.A., Gromova A.V., Kulikova N.G., Ploskireva A.A., Gorelov A.V.
Keywords
iron deficiency anemia
dysbiosis
microbiocenosis
Desulfovibrio spp
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About the Authors
Lyutsiya A. Bityumina, MD, researcher and bacteriologist at Research group for antibiotic resistance of food pathogens, Central Research Institute of Epidemiology of Rospotrebnadzor. Address: 111123, Moscow, 3A Novogireevskaya St.E-mail: bitumina@cmd.su
ORCID: https://orcid.org/0000-0002-5378-0827
Irina B. Koroleva, MD, junior researcher at Research group for antibiotic resistance of food pathogens, Central Research Institute of Epidemiology of Rospotrebnadzor. Address: 111123, Moscow, 3A Novogireevskaya St.
E-mail: martiusheva@cmd.su
ORCID: https://orcid.org/0000-0002-9397-9646
Anastasia V. Gromova, MD, PhD (Veterinary medicine), researcher at the Department of molecular diagnostics and epidemiology of reproductive organs’ infections, Central Research Institute of Epidemiology of Rospotrebnadzor. Address: 111123, Moscow, 3A Novogireevskaya St.
E-mail: anastgromow@yandex.ru
ORCID: https://orcid.org/0000-0003-4664-3178
Mikhail A. Vinokurov, MD, PhD (Medicine), researcher at the Department of molecular methods for genetic polymorphisms studying at the Central Research Institute of Epidemiology of Rospotrebnadzor. Address: 111123, Moscow, 3A Novogireevskaya St.
E-mail: vinokurov@cmd.su
ORCID: https://orcid.org/0000-0002-4101-0702
Nina G. Kulikova, MD, PhD (Biology), head of Research group for antibiotic resistance of food pathogens, Central Research Institute of Epidemiology of Rospotrebnadzor. Address: 111123, Moscow, 3A Novogireevskaya St.
E-mail: kulikova_ng@cmd.su
ORCID: https://orcid.org/0000-0002-1716-6969
Antonina A. Ploskireva, MD, Dr. Sci. (Medicine), professor, professor of RAS, deputy director for clinical work, Central Research Institute of Epidemiology of Rospotrebnadzor. Address: 111123, Moscow, 3A Novogireevskaya St.
E-mail: antoninna@mail.ru
ORCID: https://orcid.org/0000-0002-3612-1889
Alexander V. Gorelov, MD, Dr. Sci (Medicine), professor, academician of RAS, deputy director for research of Central Research Institute of Epidemiology of Rospotrebnadzor, head of the Department of infectious diseases and epidemiology, Russian University of Medicine of the Ministry of Healthcare of Russia.
E-mail: agorelov_05@mail.ru
ORCID: https://orcid.org/0000-0001-9257-0171
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