Oxidative stress indexes as potential biomarkers of chronic obstructive pulmonary disease activity
Abstract. A key innovation of the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) in 2026 became the concept of “COPD activity”. Increasing of disease activity leads to disease progression, and assessing this parameter requires searching for specific biomarkers.A.V. Budnevsky, S.N. Avdeev, E.S. Ovsyannikov, A.Ya. Kravchenko, K.V. Vostrikova, A.V. Pertsev, S.N. Feigelman
The aim: to evaluate the value of 8-isoprostane and melatonin as biomarkers of COPD activity.
Material and methods. One hundred patients in the acute phase of COPD (69 males and 31 female, clinical group E, mean age 60.5 [52.5; 68.5] years) were examined. Changes in salivary melatonin and serum 8-isoprostane levels were assessed. A correlation analysis was made between these biomarkers and the clinical and functional parameters of patients, including the frequency of hospitalizations after one year.
Results. A direct correlation was established between salivary melatonin levels and forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak expiratory flow rate (PEF), and an inverse correlation was found with the modified mMRC score. Serum 8-isoprostane levels were inversely correlated with the six-minute walk test results and spirometry parameters – FVC, FEV1, and peak expiratory flow rate 25, 50, and 75% (MOC25, MOC50, and MOC75). A direct correlation was found between 8-isoprostane concentrations and CAT and mMRC scores. By day 10, a decrease in 8-isoprostane levels and an increase in melatonin levels were observed. These results indicate the oxidant properties of 8-isoprostane and the antioxidant activity of melatonin. After one year of follow-up, statistically significant associations were found between the levels of these biomarkers and the frequency of hospitalizations.
Conclusion. The obtained data confirm that 8-isoprostane and melatonin may serve as promising biomarkers for monitoring COPD activity.
Keywords
chronic obstructive pulmonary disease
chronic obstructive pulmonary disease activity
biomarkers
melatonin
8-isoprostane
oxidative stress
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About the Authors
Andrey V. Budnevsky, MD, Dr. Sci. (Medicine), professor, Honoured Inventor of the Russian Federation, vice-rector for research and innovation, head of the Department of faculty therapy, N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation.E-mail: avbudnevski@vrngmu.ru
ORCID: https://orcid.org/0000-0002-1171-2746. еLibrary SPIN: 7381-0612. Scopus ID: 6506507539
Sergey N. Avdeev, MD, Dr. Sci. (Medicine), professor, academician of RAS, director of the Pulmonology and Respiratory Medicine Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University); head of the Department of pulmonology, head of the Clinical Department, Research Institute of Pulmonology of FMBA of Russia; chief pulmonologist of the Ministry of Healthcare of Russia, Moscow, Russian Federation.
E-mail: serg_avdeev@list.ru
ORCID: https://orcid.org/0000-0002-5999-2150. еLibrary SPIN: 1645-5524. Scopus ID: 7003292838
Evgeny S. Ovsyannikov, MD, Dr. Sci. (Medicine), professor of the Department of faculty therapy, N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation.
E-mail: ovses@yandex.ru
ORCID: https://orcid.org/0000-0002-8739-9442. еLibrary SPIN: 7999-0433. Scopus ID: 57189011728
Andrey Ya. Kravchenko, MD, Dr. Sci. (Medicine), professor of the Department of faculty therapy, N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation.
E-mail: drkay@yandex.ru
ORCID: https://orcid.org/0000-0003-0297-1735. еLibrary SPIN: 8452-1318. Scopus ID: 56684358500
Karina V. Vostrikova, MD, assistant at the Department of faculty therapy, N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation.
E-mail: prudnikova.2012@inbox.ru
ORCID: https://orcid.org/0000-0003-2103-5328. еLibrary SPIN: 9777-0358
Alexander V. Pertsev, MD, PhD (Medicine), associate professor of the Department of faculty therapy, N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation.
E-mail: pertsev.vrn@yandex.ru
ORCID: https://orcid.org/0000-0001-8984-1831. еLibrary SPIN: 1432-9076. Scopus ID: 58096896200
Sofya N. Feigelman, MD, PhD (Medicine), assistant at the Department of faculty therapy, N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation.
E-mail: s.feygelman@gmail.com
ORCID: https://orcid.org/0000-0003-4128-6044. еlibrary SPIN: 1645-1203. Scopus ID: 58996057900
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