Laryngopharyngeal reflux as an extraesophageal manifestation of gastroesophageal reflux disease
Abstract. During the autumn and winter period, outpatient physicians often encounter patients complaining of a sore throat, cough, and hoarseness. However, these symptoms are not always associated with infectious diseases. Such kind of patients are often subsequently diagnosed with laryngopharyngeal reflux (LPR), which can be an extraesophageal manifestation of gastroesophageal reflux disease (GERD). In real-world clinical practice, diagnosing LPR presents significant challenges due to the lack of pathognomonic clinical signs and a universal diagnostic tool. The most difficult for diagnosing are LPR cases without typical GERD symptoms. In this cohort of patients, developing a method for diagnosing extraesophageal GERD manifestations by measuring pepsin and bile acid levels in saliva may be a promising approach. Combined use of proton pump inhibitors with an esophageal protector is the most effective approach to GERD-associated LPR treatment.Livzan M.A., Gaus O.V., Nesterova K.I., Gavrilenko D.A., Solonenko A.P., Mozgovoi S.I.
Keywords
gastroesophageal reflux disease
laryngopharyngeal reflux
pepsin
proton pump inhibitors
esophageal protectors
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About the Authors
Maria A. Livzan, MD, Dr. Sci. (Medicine), professor, corresponding member of RAS, rector, head of the Department of faculty therapy and gastroenterology, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.E-mail: mlivzan@yandex.ru
ORCID: https://orcid.org/0000-0002-6581-7017. Scopus ID: 24341682600. eLibrary SPIN: 1961-4082
Olga V. Gaus, MD, Dr. Sci. (Medicine), associate professor, professor of the Department of faculty therapy and gastroenterology, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: gaus_olga@bk.ru
ORCID: https://orcid.org/0000-0001-9370-4768. Scopus ID: 56598554900. eLibrary SPIN: 7116-8419
Klimentina I. Nesterova, MD, Dr. Sci. (Medicine), associate professor, professor of the Department of otolaryngology, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: loromsk14@mail.ru
ORCID: https://orcid.org/0000-0002-9793-7179. Scopus ID: 8555826800. eLibrary SPIN: 9253-9964
Daria A. Gavrilenko, MD, assistant at the Department of faculty therapy and gastroenterology, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: gavrilenko_darya17@bk.ru
ORCID: https://orcid.org/0000-0001-5245-7190. Scopus ID: 58911289800. eLibrary SPIN: 1435-9150
Anna P. Solonenko, PhD (Chemistry), head of the Research Laboratory of the Faculty of dentistry, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: anna.petrovna@bk.ru
ORCID: https://orcid.org/0000-0003-4967-8464. Scopus ID: 55990443300. eLibrary SPIN: 9293-8997
Sergey I. Mozgovoi, MD, Dr. Sci. (Medicine), associate professor, professor of the Department of pathological anatomy, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: simozgovoy@yandex.ru
ORCID: https://orcid.org/0000-0001-7200-7082. Scopus ID: 8624132700. eLibrary SPIN: 4641-2099
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