Comorbid profile and hospital risks of patients in a psychosomatic department
Abstract. Currently, there is a lack of data on the clinical and pharmacological characteristics of patients with comorbid mental and somatic disorders. The aim: to study the comorbidity and incidence of complications in patients with mental and behavioral disorders hospitalized in the psychosomatic department of a multidisciplinary hospital. Materials and methods. A retrospective non-interventional study was conducted. Inclusion criteria: age > 18 years, hospitalization > 3 days, availability of complete clinical and laboratory data. Non-inclusion criteria: hospitalization lasting ≤ 3 days, presence of active oncological process, presence of active systemic disease, status after organ transplantation. Demographic indicators, mental disorders that led to hospitalization, concomitant pathology, and complications were analyzed. Results. The study included a total of 721 patients (379 men, 342 women). The main diagnoses were organic personality disorder (40.9%) and schizophrenia (23.3%). Cardiovascular diseases were detected in 66.4% of patients (predominantly hypertension and coronary artery disease). Infectious complications were registered in 50.9% of patients, non-infectious complications – in 49.2% (led by deep vein thrombosis – 16.6% and pulmonary embolism – 2.2%). A significant correlation was established between infectious complications and the duration since psychiatric diagnosis (p <0.003) and the risk of fatal outcome (p <0.001). Conclusion. The identified correlations justify the need for further analysis of risk factors for complications in psychosomatic patients to optimize management strategies.A.A. Anderzhanova, V.A. Mazus, Yu.A. Meleshkina, M.V. Zhuravleva, S.V. Yakovlev, M.V. Lukina, M.A. Balalaeva
Keywords
mental and behavioral disorders
infectious complications
non-infectious complications
comorbidity in mental disorders
concomitant diseases
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About the Authors
Anastasia A. Anderzhanova, MD, PhD (Medicine), head of the Department of clinical pharmacology, N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation.Е-mail: AnderzhanovaAA@zdrav.mos.ru,
ORCID: https://orcid.org/0000-0001-7463-8603. Scopus ID: 58188991400. eLibrary SPIN: 8065-0980
Veronika A. Mazus, MD, head of the Department of psychiatry for patients with combined somatic and mental pathology, N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation.
Е-mail: mazusva@zdrav.mos.ru
ORCID: https://orcid.org/0000-0002-3754-5333. eLibrary SPIN: 1643-8050
Yulia A. Meleshkina, MD, clinical pharmacologist at the Department of clinical pharmacology, N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation.
Е-mail: MeleshkinaYA@zdrav.mos.ru
ORCID: https://orcid.org/0000-0003-3768-6731. Scopus ID: 58188819400. eLibrary SPIN: 5088-6327
Marina V. Zhuravleva, MD, Dr. Sci. (Medicine), professor, chief clinical pharmacologist of the Department of Healthcare of Moscow; deputy director of the Center for Clinical Pharmacology, Scientific Center for Expertise of Medical Application Products, Moscow, Russian Federation.
Е-mail: ZhuravlevaMV2@zdrav.mos.ru
ORCID: https://orcid.org/0000-0002-9198-8661. Scopus ID: 55878917900. eLibrary SPIN: 6267-9901
Sergey V. Yakovlev, MD, Dr. Sci. (Medicine), professor of the Department of clinical pharmacology and therapy named after academician B.E. Votchal, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia; clinical pharmacologist at the Department of clinical pharmacology, N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation.
Е-mail: antimicrob@yandex.ru
ORCID: https://orcid.org/0000-0001-7606-8608. Scopus ID: 7006718466. eLibrary SPIN: 9313-1453
Maria V. Lukina, MD, PhD (Medicine), clinical pharmacologist at the Department of clinical pharmacology, N.I. Pirogov City Clinical Hospital No. 1; senior researcher at the Centralized Department of Clinical Pharmacology, Academician B.V. Petrovsky Russian Scientific Center of Surgery, Moscow, Russian Federation.
Е-mail: mari-luk2010@yandex.ru
ORCID: https://orcid.org/0000-0003-0032-2651. Scopus ID: 57090313500. eLibrary SPIN: 4570-6074
Maria A. Balalaeva, MD, PhD (Medicine), clinical pharmacologist at the Department of clinical pharmacology, N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation.
Е-mail: BalalaevaMA@zdrav.mos.ru
ORCID: https://orcid.org/0000-0001-5968-3297. Scopus ID: 57176306600. eLibrary SPIN: 9267-5440
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