Chronic gastritis: Clinical, diagnostic, psychovegetative peculiarities and life quality of the patients
Abstract. The role of the autonomic nervous system in the development and progression of chronic gastritis remains to be largely unknown. The aim: to estimate the clinical, laboratory, and instrumental characteristics of H. pylori-positive (Hp(+)) and H. pylori-negative (Hp(-)) chronic gastritis, taking into account clinical, laboratory, and instrumental diagnostic methods, and their correlation with individual patient psychovegetative characteristics and life quality indexes. Material and methods. The study included 122 patients with chronic gastritis, aged 25 to 60 years. They were divided into two groups: 62 individuals with Hp(+) and 60 with Hp(-). All participants underwent clinical, laboratory, and instrumental examinations (GastroPanel® test system and esophagogastroduodenoscopy with gastric mucosal biopsy using the OLGA/OLGIM system). Autonomic nervous system estimation was performed using cardiointervalograms processed by Korveg software. Testing was performed using Hospital Anxiety and Depression Scale (HADS), Giessen questionnaire, and the Nottingham Health Profile (NHP) questionnaire for life quality estimation. The control group consisted of 30 healthy individuals. Results. Significant differences in the presence of metaplasia were found between the study groups. It was detected only in participants with Hp(+) gastritis. Baseline vegetative tonus (vagotonia) was significantly more frequent in the groups of patients with chronic gastritis than in controls (73.1 vs. 10%, p = 0.001). There were no significant differences in the frequency of vagotonia, sympathicotonia, and eutonia between the Hp(-) and Hp(+) groups. Regardless of Hp status, patients with chronic gastritis, compared to the control group, showed a decrease in quality of life, measured on the sleep (p = 0.001) and energy (p = 0.002) scales. According to the Giessen Questionnaire, in the studied group of patients gastrointestinal complaints were predominating (p <0.001). Conclusion. Patients with chronic gastritis, regardless of Hp status, showed increased parasympathetic activity at rest and increased sympathicotonia during exercise regimens. Psychological status indicators (anxiety and depression levels, pattern of somatic complaints) and quality of life did not differ depending on the presence or absence of H. pylori infection.A.O. Kutsayeva, M.A. Nikonorova, M.A. Sinkov, E.Yu. Plotnikova
Keywords
gastritis
Helicobacter pylori
psychovegetative peculiarities
life quality
cardiointervalography
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About the Authors
Alena O. Kutsayeva, MD, gastroenterologist, I.A. Kolpinsky Clinical Consultative and Diagnostic Center, Kemerovo, Russian Federation.E-mail: dr.kytsaeva@vk.com
ORCID: https://orcid.org/0009-0006-2396-3880
Marina A. Nikonorova, MD, Dr. Sci.(Medicine), associate professor, professor of the Department of infectious diseases with continuing professional education, Altai State Medical University, Barnaul, Russian Federation.
E-mail: ma.nikulina@mail.ru
ORCID: https://orcid.org/0000-0001-6621-9310. Scopus ID: 57222869049. eLibrary SPIN: 5396-5198
Maxim A. Sinkov, MD, PhD (Medicine), cardiovascular surgeon, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
E-mail: fox2you@mail.ru
ORCID: https://orcid.org/0000-0002-2494-8694. Scopus ID: 57189646155. eLibrary SPIN: 8327-3979
Ekaterina Yu. Plotnikova, MD, Dr. Sci. (Medicine), professor, professor of the Department of faculty therapy and geriatrics, Altai State Medical University; professor of the Department of postgraduate training and nursing, head of the course of clinical gastroenterology, Kemerovo State Medical University, Kemerovo, Russian Federation.
E-mail: eka-pl@rambler.ru
ORCID: https://orcid.org/0000-0002-6150-1808. Scopus ID: 57193910407. eLibrary SPIN: 4346-5012
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