ISSN 2412-4036 (print)
ISSN 2713-1823 (online)

Hypercalcemia syndrome: Diagnostic search and approaches to therapy

Biryukova E.V., Shinkin M.V., Mkrtumyan A.M., Morozova I.A.

1) Russian University of Medicine of the Ministry of Healthcare of Russia, Moscow; 2) A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow
Abstract. Hypercalcemia syndrome (HC) is a calcium-phosphorus metabolism disorder that often taking place in clinical practice. Literature review presents current data on the main aspects of calcium homeostasis, the level of which is strictly supervised by hormonal control; the role and mechanisms of calcium-regulating hormones action are also considered, and various causes of HC are highlighted. Article describes the clinical picture of hypercalcemia syndrome and approaches to differential diagnostics in various clinical situations. Particular attention is paid to the symptoms, diagnostics and modern methods of treatment of primary hyperparathyroidism – the one of the leading causes of HC development.

Keywords

hypercalcemia
calcium
parathyroid hormone
vitamin D
primary hyperparathyroidism
postoperative hypocalcemia

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About the Authors

Elena V. Biryukova, MD, Dr. Sci. (Medicine), professor of the Department of endocrinology and diabetology, Russian University of Medicine of the Ministry of Healthcare of Russia. Address: 127006, Moscow, 4 Dolgorukovskaya St.
E-mail: lena@obsudim.ru
ORCID: https://orcid.org/0000-0001-9007-4123. Scopus ID: 55344795700. eLibrary SPIN: 3700-9150
Mikhail V. Shinkin, MD, researcher at the Department of endocrine and metabolic diseases, endocrinologist at A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow. Address: 111123, Moscow, 86 Entuziastov Highway.
E-mail: m.shinkin@mknc.ru
ORCID: https://orcid.org/0000-0003-1548-1487. Scopus ID: 57266354400. eLibrary SPIN: 2684-1579
Ashot M. Mkrtumyan, MD, Dr. Sci. (Medicine), professor, head of the Department of endocrinology and diabetology, Russian University of Medicine of the Ministry of Healthcare of Russia, head of the Department of endocrine and metabolic diseases, A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow. Address: 127006, Moscow, 4 Dolgorukovskaya St.
E-mail: vagrashot@mail.ru
ORCID: https://orcid.org/0000-0003-1316-5245. Scopus ID: 6602962407. eLibrary SPIN: 1980-8700
Irina A. Morozova, MD, PhD (Medicine), senior researcher at the Department of endocrine and metabolic diseases, A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow. Address: 111123, Moscow, 86 Entuziastov Highway.
E-mail: i.morozova@mknc.ru
ORCID: https://orcid.org/0000-0002-1939-261X. eLibrary SPIN: 3272-3387

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