ISSN 2412-4036 (print)
ISSN 2713-1823 (online)

Diagnostic capabilities of the analysis of exhaled air biochemical composition in respiratory diseases

Teteneva A.V., Bespalova I.D., Yarovoy N.D., Chernov V.I., Sachkov V.I., Sorokina T.V., Nesterovich S.V., Radionov D.I., Radionova E.V.

1) Siberian State Medical University of the Ministry of Healthcare of Russia, Tomsk; 2) Primary Healthcare Unit No. 2 of the Department of Healthcare Tomsk region, Tomsk; 3) Tomsk National Research Medical Center of the Russian Academy of Sciences; 4) National Research Tomsk State University; 5) Minusinsk Interdistrict Hospital
Abstract. Respiratory diseases diagnostics is a complex task for modern medicine, especially when using traditional methods associated with invasiveness and risks for patients. Exhaled air analysis based on the study of volatile organic compounds offers a non-invasive, rapid and accurate approach for detecting diseases such as chronic obstructive pulmonary disease, asthma, lung cancer, pneumonia and COVID-19. The aim of the research is to evaluate the diagnostic capabilities of exhaled air biochemical analysis for detection of various respiratory pathologies and determine the key advantages and limitations of this method. Exhaled air analysis is a promising diagnostic tool due to its non-invasiveness, high sensitivity and the possibility of repeated use. Despite the need for standardization of the method, its use has significant potential for improving the diagnosis and monitoring of respiratory diseases in clinical practice.

Keywords

exhaled air
biomarkers of respiratory diseases
volatile organic compounds
chronic obstructive pulmonary disease
asthma
lung cancer
COVID-19
pneumonia
tuberculosis

References

1. Hashoul D, Haick H. Sensors for detecting pulmonary diseases from exhaled breath. Eur Respir Rev. 2019;28(152):190011.

PMID: 31243097. PMCID: PMC9489036. https://doi.org/10.1183/16000617.0011-2019

2. van de Kant KDG, van der Sande LJTM, Jobsis Q, van Schayck OCP, Dompeling E. Clinical use of exhaled volatile organic compounds in pulmonary diseases: A systematic review. Respir Res. 2012;13(1):117.

PMID: 23259710. PMCID: PMC3549749. https://doi.org/10.1186/1465-9921-13-117

3. Hunt J. Exhaled breath condensate: An evolving tool for noninvasive evaluation of lung disease. J Allergy Clin Immunol. 2002;110(1):28–34.

PMID: 12110814. https://doi.org/10.1067/MAI.2002.124966

4. Popov TA. Human exhaled breath analysis. Ann Allergy Asthma Immunol. 2011;106(6):451–57.

PMID: 21624743. https://doi.org/10.1016/j.anai.2011.02.016

5. Pereira J, Porto-Figueira P, Cavaco C, Taunk K, Rapole S, Dhakne R et al. Breath analysis as a potential and non-Invasive frontier in disease diagnosis: An overview. Metabolites. 2015;5(1):3–55.

PMID: 25584743. PMCID: PMC4381289. https://doi.org/10.3390/metabo5010003

6. Cepelak I, Dodig S. Exhaled breath condensate: A new method for lung disease diagnosis. Clin Chem Lab Med. 2007;45(8):945–52.

PMID: 17867983. https://doi.org/10.1515/cclm.2007.326

7. Fens N, Zwinderman AH, van der Schee MP, de Nijs SB, Dijkers E, Roldaan AC et al. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med. 2009;180(11):1076–82.

PMID: 19713445. https://doi.org/10.1164/rccm.200906-0939OC

8. Aroutiounian VM. Exhaled breath semiconductor sensors for diagnostics of respiratory diseases. Armenian Journal of Physics. 2022;15(1):13–24.

https://doi.org/10.54503/18291171-2022.15.1-13

9. Ibrahim W, Carr L, Cordell R, Wilde MJ, Salman D, Monks PS et al. Breathomics for the clinician: The use of volatile organic compounds in respiratory diseases. Thorax. 2021;76(6):514–21.

PMID: 33414240. PMCID: PMC7611078. https://doi.org/10.1136/thoraxjnl-2020-215667

10. Amann A, Miekisch W, Schubert J, Buszewski B, Ligor T, Jezierski T et al. Analysis of exhaled breath for disease detection. Annu Rev Anal Chem (Palo Alto Calif). 2014;7:455–82.

PMID: 25014347. https://doi.org/10.1146/annurev-anchem-071213-020043

11. Wallace MAG, Pleil JD. Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols. Anal Chim Acta. 2018;1024:18–38.

PMID: 29776545. PMCID: PMC6082128. https://doi.org/10.1016/j.aca.2018.01.069

12. Konstantinidi EM, Lappas AS, Tzortzi AS, Behrakis PK. Exhaled breath condensate: Technical and diagnostic aspects. ScientificWorldJournal. 2015;2015:435160.

PMID: 26106641. PMCID: PMC4461795. https://doi.org/10.1155/2015/435160

13. Chien P-J, Suzuki T, Tsujii M, Ye M, Toma K, Arakawa T et al. Bio-sniffer (gas-phase biosensor) with secondary alcohol dehydrogenase (S-ADH) for determination of isopropanol in exhaled air as a potential volatile biomarker. Biosens Bioelectron. 2017;91:341–46.

PMID: 28043076. https://doi.org/10.1016/j.bios.2016.12.050

14. Maximova EN, Markov VF, Bezdetnova AE, Shashmurin YuG, Maskaeva LN, Dyakov VF. Using of chemical sensors for rapid diagnostic tests of exhaled air. Butlerov Communications. 2019;60(12):25–28.

https://doi.org/10.37952/roi-jbc-01/19-60-12-25

15. Smith D, Spanel P, Herbig J, Beauchamp J. Mass spectrometry for real-time quantitative breath analysis. J Breath Res. 2014;8(2):027101.

PMID: 24682047. https://doi.org/10.1088/1752-7155/8/2/027101

16. Lawal O, Ahmed WM, Nijsen TME, Goodacre R, Fowler SJ. Exhaled breath analysis: A review of ‘breath-taking’ methods for off-line analysis. Metabolomics. 2017;13(10):110.

PMID: 28867989. PMCID: PMC5563344. https://doi.org/10.1007/s11306-017-1241-8

17. Almstrand A-C, Josefson M, Bredberg A, Lausmaa J, Sjövall P, Larsson P, Olin A-C. TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls. Eur Respir J. 2011;39(1):59–66.

PMID: 21719486. https://doi.org/10.1183/09031936.00195610

18. Montuschi P, Corradi M, Ciabattoni G, Nightingale J, Kharitonov SA, Barnes PJ. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am J Respir Crit Care Med. 1999;160(1):216–20.

PMID: 10390403. https://doi.org/10.1164/ajrccm.160.1.9809140

19. Battaglia S, den Hertog H, Timmers MC, Lazeroms SPG, Vignola AM, Rabe KF et al. Small airways function and molecular markers in exhaled air in mild asthma. Thorax. 2005;60(8):639–44.

PMID: 16061704. PMCID: PMC1747499. https://doi.org/10.1136/thx.2004.035279

20. Kharitonov SA, Chung KF, Evans D, O’Connor BJ, Barnes PJ. Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am J Respir Crit Care Med. 1996;153(6 Pt 1):1773–80.

PMID: 8665033. https://doi.org/10.1164/AJRCCM.153.6.8665033

21. Ragnoli B, Radaeli A, Pochetti P, Kette S, Morjaria J, Malerba M. Fractional nitric oxide measurement in exhaled air (FeNO): Perspectives in the management of respiratory diseases. Ther Adv Chronic Dis. 2023;14:20406223231190480.

PMID: 37538344. PMCID: PMC10395178. https://doi.org/10.1177/20406223231190480

22. Carraro S, Rezzi S, Reniero F, Héberger K, Giordano G, Zanconato S et al. Metabolomics applied to exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med. 2007;175(10):986–90.

PMID: 17303796. https://doi.org/10.1164/rccm.200606-769OC

23. Neerincx AH, Vijverberg SJH, Bos LDJ, Brinkman P, van der Schee MP, de Vries R et al. Breathomics from exhaled volatile organic compounds in pediatric asthma. Pediatr Pulmonol. 2017;52(12):1616–27.

PMID: 29082668. https://doi.org/10.1002/ppul.23785

24. Azim A, Barber C, Dennison P, Riley J, Howarth P. Exhaled volatile organic compounds in adult asthma: A systematic review. Eur Respir J. 2019;54(3):1900056.

PMID: 31273044. https://doi.org/10.1183/13993003.00056-2019

25. Титова Н.Д., Новиков П.Д. Рекомендации по диагностике и противорецидивному лечению бронхиальной астмы у детей дошкольного возраста. Иммунопатология, аллергология, инфектология. 2020;(1):63–70. (Titova ND, Novikov PD. Recommendations for diagnosis and anti-relapse treatment of bronchial asthma in preschool children. Immunopatologiya, allergologiya, infektologiya = Immunopathology, Allergology, Infectology. 2020;(1):63–70 (In Russ.)).

EDN: FECEPD. https://doi.org/10.14427/jipai.2020.1.63

26. Khamas SS, Bahmani AHA, Vijverberg SJH, Brinkman P, van der Zee AHM. Exhaled volatile organic compounds associated with risk factors for obstructive pulmonary diseases: A systematic review. ERJ Open Res. 2023;9(4):00143-2023.

PMID: 37650089. PMCID: PMC10463028. https://doi.org/10.1183/23120541.00143-2023

27. Силантьев А.С., Туттер Д.С., Быкова А.А., Кардонский Д.А., Бетелин В.Б., Чомахидзе П.Ш., Копылов Ф.Ю. Волатомика в здравоохранении: технические основы и клиническое применение. Российский журнал персонализированной медицины. 2023;3(1):98–108. (Silantyev AS, Tuter DS, Bykova AA, Kardonsky DA, Betelin VB, Chomakhidze PSh, Kopylov FYu. Volatomics in healthcare: Technical basis and clinical application. Rossiiskiy zhurnal personalizirovannoy meditsiny = Russian Journal of Personalized Medicine. 2023;3(1):98–108 (In Russ.)).

EDN: TLTRWT. https://doi.org/10.18705/2782-3806-2023-3-1-98-108

28. Cazzola M, Segreti A, Capuano R, Bergamini A, Martinelli E, Calzetta L et al. Analysis of exhaled breath fingerprints and volatile organic compounds in COPD. COPD Research and Practice. 2015;1:1–8.

https://doi.org/10.1186/S40749-015-0010-1

29. Gaugg MT, Nussbaumer-Ochsner Y, Bregy L, Engler A, Stebler N, Gaisl T et al. Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations. Chest. 2019;156(2):269–76.

PMID: 30685334. https://doi.org/10.1016/j.chest.2018.12.023

30. Kharitonov SA, Barnes PJ. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers. 2002;7(1):1–32.

PMID: 12101782. https://doi.org/10.1080/13547500110104233

31. Antus B, Kardos Z. Oxidative stress in COPD: Molecular background and clinical monitoring. Curr Med Chem. 2015;22(5):627–50.

PMID: 25585265. https://doi.org/10.2174/092986732205150112104411

32. Mutti A, Corradi M, Goldoni M, Vettori MV, Bernard A, Apostoli P. Exhaled metallic elements and serum pneumoproteins in asymptomatic smokers and patients with COPD or asthma. Chest. 2006;129(5):1288–97.

PMID: 16685021. PMCID: PMC1472634. https://doi.org/10.1378/chest.129.5.1288

33. Глухова М.В. Маркеры воспаления в диагностике легкой бронхиальной астмы у детей. Дисс. … канд. мед. наук. М. 2022; 102 с. Доступ: https://www.dissercat.com/content/markery-vospaleniya-v-diagnostike-legkoi-bronkhialnoi-astmy-u-detei (дата обращения – 07.05.2025). (Glukhova MV. Markers of inflammation in the diagnosis of mild bronchial asthma in children. Dissertation for the title of PhD in Medical Sciences. Moscow. 2022; 102 pp. URL: https://www.dissercat.com/content/markery-vospaleniya-v-diagnostike-legkoi-bronkhialnoi-astmy-u-detei (date of access – 07.05.2025) (In Russ.)). EDN: NFNDCA.

34. Majewska E, Kasielski M, Luczyński R, Bartosz G, Białasiewicz P, Nowak D. Elevated exhalation of hydrogen peroxide and thiobarbituric acid reactive substances in patients with community acquired pneumonia. Respir Med. 2004;98(7):669–76.

PMID: 15250234. https://doi.org/10.1016/j.rmed.2003.08.015

35. Boshier PR, Mistry V, Cushnir JR, Curtis S, Elkin S, Kon OM et al. S128 Analysis of volatile biomarkers within exhaled breath for the diagnosis of pneumonia. Thorax. 2010;65:A58–A59.

https://doi.org/10.1136/thx.2010.150946.29

36. van Oort PMP, de Bruin S, Weda H, Knobel HH, Schultz MJ, Bos LD on behalf of The Mars Consortium. Exhaled breath metabolomics for the diagnosis of pneumonia in intubated and mechanically-ventilated intensive care unit (ICU)-patients. Int J Mol Sci. 2017;18(2):449.

PMID: 28218729. PMCID: PMC5343983. https://doi.org/10.3390/ijms18020449

37. Carraro S, Andreola B, Alinovi R, Corradi M, Freo L, Da Dalt L, Baraldi E. Exhaled leukotriene B4 in children with community acquired pneumonia. Pediatr Pulmonol. 2008;43(10):982–86.

PMID: 18781641. https://doi.org/10.1002/ppul.20889

38. van Oort PM, Póvoa P, Schnabel R, Dark P, Artigas A, Bergmans DCJJ et al. The potential role of exhaled breath analysis in the diagnostic process of pneumonia – a systematic review. J Breath Res. 2018;12(2):024001.

PMID: 29292698. https://doi.org/10.1088/1752-7163/aaa499

39. Raman R, Patel KJ, Ranjan K. COVID-19: Unmasking emerging SARS-CoV-2 variants, vaccines and therapeutic strategies. Biomolecules. 2021;11(7):993.

PMID: 34356617. PMCID: PMC8301790. https://doi.org/10.3390/biom11070993

40. Wallace MAG, Pleil JD. Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols. Anal Chim Acta. 2018;1024:18–38.

PMID: 29776545. PMCID: PMC6082128. https://doi.org/10.1016/j.aca.2018.01.069

41. Yang L, Zhou W, Ma J, Sun L, Zhai D, Ren G-Q et al. Ultrafast screening of COVID-19 by machine learning analysis of exhaled NO. Research Square. 2020.

https://doi.org/10.21203/rs.3.rs-56416/v1

42. Grassin-Delyle S, Roquencourt C, Moine P, Saffroy G, Carn S., Heming N et al.; Garches COVID-19 Collaborative Group RECORDS Collaborators and Exhalomics® Collaborators. Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study. EBioMedicine. 2020;63:103154.

PMID: 33279860. PMCID: PMC7714658. https://doi.org/10.1016/j.ebiom.2020.103154

43. Ibrahim W, Cordell RL, Wilde MJ, Richardson M, Carr L, Dasi ASD et al. Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography – mass spectrometry. ERJ Open Res. 2021;7(3):00139-2021.

PMID: 34235208. PMCID: PMC8255539. https://doi.org/10.1183/23120541.00139-2021

44. Barberis E, Amede E, Khoso S, Castello L, Sainaghi PP, Bellan M et al. Metabolomics diagnosis of COVID-19 from exhaled breath condensate. Metabolites. 2021;11(12):847.

PMID: 34940605. PMCID: PMC8708149. https://doi.org/10.3390/metabo11120847

45. Duan C, Buerer L, Wang J, Kaplan S, Sabalewski G, Jay GD et al. Efficient detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from exhaled breath. J Mol Diagn. 2021;23(12):1661–70.

PMID: 34600137. PMCID: PMC8480135. https://doi.org/10.1016/j.jmoldx.2021.09.005

46. Ghumra DP, Shetty N, McBrearty KR, Puthussery JV, Sumlin BJ, Gardiner WD et al. Rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care. ACS Sens. 2023;8(8):3023–31.

PMID: 37498298. PMCID: PMC10463275. https://doi.org/10.1021/acssensors.3c00512

47. Susanto AD, Agustin H, Taufik M, Rahman MA, Hidayat M. Accuracy of volatile organic compound (VOC) detection in exhaled breath compared to reverse-transcriptase polymerase chain reaction (RT-PCR) for diagnosis of COVID-19: An evidence-based case report. Archives of Clinical Infectious Diseases. 2022;17(5):e119263.

https://doi.org/10.5812/archcid-119263

48. Nwanochie E, Linnes JC. Review of non-invasive detection of SARS-CoV-2 and other respiratory pathogens in exhaled breath condensate. J Breath Res. 2022;16(2):10.1088/1752-7163/ac59c7.

PMID: 35235925. PMCID: PMC9104940. https://doi.org/10.1088/1752-7163/ac59c7

49. Giovannini G, Haick H, Garoli D. Detecting COVID-19 from breath: A game changer for a big challenge. ACS Sens. 2021;6(4):1408–17.

PMID: 33825440. PMCID: PMC8043202. https://doi.org/10.1021/acssensors.1c00312

50. Sutaria SR, Gori SS, Morris JD, Xie Z, Fu X-A, Nantz MH. Lipid peroxidation produces a diverse mixture of saturated and unsaturated aldehydes in exhaled breath that can serve as biomarkers of lung cancer – a review. Metabolites. 2022;12(6):561.

PMID: 35736492. PMCID: PMC9229171. https://doi.org/10.3390/metabo12060561

51. Ligor M, Ligor T, Bajtarevic A, Ager C, Pienz M, Klieber M et al. Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry. Clin Chem Lab Med. 2009;47(5):550–60.

PMID: 19397483. https://doi.org/10.1515/cclm.2009.133

52. Wang C, Dong R, Wang X, Lian A, Chi C, Ke C et al. Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation. Sci Rep. 2014;4:7312.

PMID: 25482491. PMCID: PMC4258651. https://doi.org/10.1038/srep07312

53. Sakumura Y, Koyama Y, Tokutake H, Hida T, Sato K, Itoh T et al. Diagnosis by volatile organic compounds in exhaled breath from lung cancer patients using support vector machine algorithm. Sensors (Basel). 2017;17(2):287.

PMID: 28165388. PMCID: PMC5335963. https://doi.org/10.3390/s17020287

54. Bajtarevic A, Ager C, Pienz M, Klieber M, Schwarz K, Ligor M et al. Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer. 2009;9:348.

PMID: 19788722. PMCID: PMC2761408. https://doi.org/10.1186/1471-2407-9-348

55. Gaspar EM, Lucena AF, da Costa JD, das Neves HC. Organic metabolites in exhaled human breath – a multivariate approach for identification of biomarkers in lung disorders. J Chromatogr A. 2009;1216(14):2749–56.

PMID: 19036381. https://doi.org/10.1016/j.chroma.2008.10.125

56. Oguma T, Nagaoka T, Kurahashi M, Kobayashi N, Yamamori S, Tsuji C et al. Clinical contributions of exhaled volatile organic compounds in the diagnosis of lung cancer. PLoS One. 2017;12(4):e0174802.

PMID: 28384298. PMCID: PMC5383041. https://doi.org/10.1371/journal.pone.0174802

57. Gashimova EM, Temerdashev AZ, Porkhanov VA, Polyakov IS, Perunov DV, Osipova AK, Dmitrieva EV. Assessment of a possibility to differentiate the tumor histological type and localization in patients with lung cancer by the composition of exhaled air. Journal of Analytical Chemistry. 2021;76:975–80.

https://doi.org/10.1134/S1061934821080050

58. Guzman-Beltran S, Carreto-Binaghi LE, Carranza C, Torres M, Gonzalez Y, Munoz-Torrico M, Juárez E. Oxidative stress and inflammatory mediators in exhaled breath condensate of patients with pulmonary tuberculosis. A pilot study with a biomarker perspective. Antioxidants (Basel). 2021;10(10):1572.

PMID: 34679707. PMCID: PMC8533495. https://doi.org/10.3390/antiox10101572

59. Phillips M, Cataneo RN, Condos R, Erickson GAR, Greenberg J, La Bombardi V et al. Volatile biomarkers of pulmonary tuberculosis in the breath. Tuberculosis (Edinb). 2007;87(1):44–52.

PMID: 16635588. https://doi.org/10.1016/j.tube.2006.03.004

60. Zetola NM, Modongo C, Matsiri O, Tamuhla T, Mbongwe B, Matlhagela K et al. Diagnosis of pulmonary tuberculosis and assessment of treatment response through analyses of volatile compound patterns in exhaled breath samples. J Infect. 2017;74(4):367–76.

PMID: 28017825. PMCID: PMC5337142. https://doi.org/10.1016/j.jinf.2016.12.006

61. Wang CH, Liu CY, Lin HC, Yu CT, Chung KF, Kuo HP. Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages. Eur Respir J. 1998;11(4): 809–15.

PMID: 9623681. https://doi.org/10.1183/09031936.98.11040809

62. Patterson B, Morrow C, Singh V, Moosa A, Gqada M, Woodward J et al. Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients. Gates Open Res. 2017;1:11.

PMID: 29355225. PMCID: PMC5757796. https://doi.org/10.12688/gatesopenres.12758.2

63. Chen D, Bryden NA, Bryden WA, McLoughlin M, Smith D, Devin AP et al. Non-volatile organic compounds in exhaled breath particles correspond to active tuberculosis. Sci Rep. 2022;12(1):7919.

PMID: 35562381. PMCID: PMC9106714. https://doi.org/10.1038/s41598-022-12018-6

64. Griese M, Noss J, Schramel P. Elemental and ion composition of exhaled air condensate in cystic fibrosis. J Cyst Fibros. 2003;2(3):136–42.

PMID: 15463862. https://doi.org/10.1016/S1569-1993(03)00062-6

65. Montuschi P, Kharitonov SA, Ciabattoni G, Corradi M, van Rensen L, Geddes DM et al. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax. 2000;55(3):205–9.

PMID: 10679539. PMCID: PMC1745696. https://doi.org/10.1136/thorax.55.3.205

66. Lucidi V, Ciabattoni G, Bella S, Barnes PJ, Montuschi P. Exhaled 8-isoprostane and prostaglandin E(2) in patients with stable and unstable cystic fibrosis. Free Radic Biol Med. 2008;45(6):913–19.

PMID: 18634869. https://doi.org/10.1016/j.freeradbiomed.2008.06.026

67. Paredi P, Kharitonov SA, Leak D, Shah PL, Cramer D, Hodson ME, Barnes PJ. Exhaled ethane is elevated in cystic fibrosis and correlates with carbon monoxide levels and airway obstruction. Am J Respir Crit Care Med. 2000;161(4 Pt 1):1247–51.

PMID: 10764319. https://doi.org/10.1164/ajrccm.161.4.9906122

68. Carpagnano GE, Barnes PJ, Geddes DM, Hodson ME, Kharitonov SA. Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis. Am J Respir Crit Care Med. 2003;167(8):1109–12.

PMID: 12684249. https://doi.org/10.1164/rccm.200203-179OC

69. Paredi PL, Shah P, Montuschi P, Sullivan P, Hodson ME, Kharitonov SA, Barnes PJ. Increased carbon monoxide in exhaled air of patients with cystic fibrosis. Thorax. 1999;54(10):917–20.

PMID: 10491455. PMCID: PMC1745371. https://doi.org/10.1136/thx.54.10.917

70. Barker M, Hengst M, Schmid J, Buers H-J, Mittermaier B, Klemp D, Koppmann R. Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis. Eur Respir J. 2006;27(5):929–36.

PMID: 16455833. https://doi.org/10.1183/09031936.06.00085105

71. Robroeks CMHHT, van Berkel JJBN, Dallinga JW, Jöbsis Q, Zimmermann LJI, Hendriks HJE et al. Metabolomics of volatile organic compounds in cystic fibrosis patients and controls. Pediatr Res. 2010;68(1):75–80.

PMID: 20351658. https://doi.org/10.1203/pdr.0b013e3181df4ea0

72. Gaisl T, Bregy L, Stebler N, Gaugg MT, Bruderer T, García-Gómez D et al. Real-time exhaled breath analysis in patients with cystic fibrosis and controls. J Breath Res. 2018;12(3):036013.

PMID: 29555894. https://doi.org/10.1088/1752-7163/aab7fd

About the Authors

Anna V. Teteneva, MD, Dr. Sci. (Medicine), professor of the Department of propaedeutics of internal diseases with a course in therapy of the Faculty of pediatrics, Siberian State Medical University of the Ministry of Healthcare of Russia, deputy chief physician for clinical and expertise work of Primary Healthcare Unit No. 2 of the Department of Healthcare of Tomsk region. Address: 634050, Tomsk, 2 Moskovsky Tract.
E-mail: anna.dubodelova@mail.ru
ORCID: https://orcid.org/0000-0002-4323-2798. Scopus ID: 57214109808. eLibrary SPIN: 9472-4472
Inna D. Bespalova, MD, Dr. Sci. (Medicine), head and professor of the Department of propaedeutics of internal diseases with a course in therapy of the Faculty of pediatrics, Siberian State Medical University of the Ministry of Healthcare of Russia. Address: 634050, Tomsk, 2 Moskovsky Tract.
E-mail: bespalova.id@ssmu.ru
ORCID: https://orcid.org/0000-0002-4513-6329. Scopus ID: 55820749900. eLibrary SPIN: 6852-6200
Nikolay D. Yarovoy, resident of the Department of biochemistry and molecular biology with the course of clinical laboratory diagnostics, Siberian State Medical University of the Ministry of Healthcare of Russia, physician-statistician of Primary Healthcare Unit No. 2 of the Department of Healthcare of Tomsk region. Address: 634050, Tomsk, 2 Moskovsky Tract.
E-mail: koly-yarovoy@yandex.ru
ORCID: https://orcid.org/0000-0003-3619-6095. eLibrary SPIN: 1707-4330
Vladimir I. Chernov, MD, Dr. Sci. (Medicine), professor, corresponding member of RAS, deputy director for research and innovation work, Tomsk National Research Medical Center of the Russian Academy of Sciences, head of the Department of radionuclide therapy and diagnostics of the Research institute of oncology, Tomsk National Research Medical Center of the Russian Academy of Sciences. Address: 634009, Tomsk, 5 Kooperativny Lane.
E-mail: achernov@tnimc.ru
ORCID: https://orcid.org/0000-0001-8753-7916
Viktor I. Sachkov, Dr. Sci. (Chemistry), associate professor, head of the Department of chemical technologies, head of the Innovation and Technology Center of Siberian Physics and Technology Institute, National Research Tomsk State University. Address: 634050, Tomsk, 36 Lenina Avenue.
E-mail: Vicsachkov@outlook.com
ORCID: https://orcid.org/0000-0001-7866-274X
Tatiana V. Sorokina, MD, head of the Therapeutic Clinic – therapist at Siberian State Medical University of the Ministry of Healthcare of Russia. Address: 634050, Tomsk, 2 Moskovsky Tract.
E-mail: gbsmp.sorokinatatyana@mail.ru
ORCID: https://orcid.org/0000-0002-6264-4632
Sofia V. Nesterovich, MD, PhD (Medicine), chief physician of Siberian State Medical University of the Ministry of Healthcare of Russia. Address: 634050, Tomsk, 2 Moskovsky Tract.
E-mail: nesterovich.sv@ssmu.ru
ORCID: https://orcid.org/0000-0003-2098-2964
Denis I. Radionov, MD, therapist at Minusinsk Interdistrict Hospital. Address: 662606, Minusinsk, 2a Botanicheskaya St.
E-mail: radionovdenis12@gmail.ru
ORCID: https://orcid.org/0009-0004-2863-2736
Ekaterina V. Radionova, MD, therapist at Minusinsk Interdistrict Hospital. Address: 662606, Minusinsk, 2a Botanicheskaya St.
E-mail: Opoldnik@yandex.ru
ORCID: https://orcid.org/0000-0002-0696-2951

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