Favorable course of pregnancy in a patient with rituximab-induced remission of granulomatosis with polyangiitis
Abstract. Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease affecting small and medium-caliber arteries and mainly affecting the ENT organs, lungs and kidneys. Pregnancy in GPA patients is rare due to the development of the disease in most females over the age of 40–50 years. At the same time, when these conditions are combined, there is a high risk of exacerbation of GPA, which is life-threatening for the mother and requires the use of aggressive immunosuppression with potentially teratogenic drugs, which further increases the risk of complications for the fetus. Management of such a pregnancy requires careful monitoring and an interdisciplinary approach. Article contains a clinical observation of a young patient with severe lung damage associated with GPA, including the stages of diagnosis, selection of therapy, pregnancy and postpartum period. The aim of describing the presented clinical case is to illustrate the possibilities of a favorable pregnancy outcome for the mother and child when planning it during the period of GPA remission.Yupatova M.I., Nikitina N.M., Rebrov A.P.
Keywords
granulomatosis with polyangiitis
pregnancy
rituximab
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About the Authors
Maria I. Yupatova, MD, assistant at the Department of hospital therapy of the Institute of clinical medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol’shaya Kazachya St.E-mail: agent.smi@mail.ru
ORCID: https://orcid.org/0000-0001-8120-4424. Scopus ID: 59315471700. eLibrary SPIN: 4436-4561
Natalya M. Nikitina, MD, Dr. Sci. (Medicine), head of the Department of hospital therapy of the Institute of clinical medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol’shaya Kazachya St.
E-mail: nikina02@yandex.ru
ORСID: https://orcid.org/0000-0002-0313-1191. Scopus ID: 24338688700. eLibrary SPIN: 6661-1830
Andrey P. Rebrov, MD, Dr. Sci. (Medicine), professor of the Department of hospital therapy of the Institute of clinical medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia, plenipotentiary representative of RSMSIM in the Volga Federal District. Address: 410012, Saratov, 112 Bol’shaya Kazachya St.
E-mail: aprebrov@yandex.ru
ORCID: https://orcid.org/0000-0002-3463-7734. Scopus ID: 7005047527. eLibrary SPIN: 9574-2067
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