Alternative possibilities for bronchial asthma controlling in individuals with high cardiorespiratory risk
Abstract. Cardiovascular pathology is a frequent comorbid condition in case of bronchial asthma (BA) presence. BA exacerbations and uncontrolled use of short-acting bronchodilators (SABA) increase cardiorespiratory risk. The use of a combination of inhaled glucocorticosteroids (ICS) / long-acting β2-agonists or ICS/SABA instead of SABA as symptomatic therapy for bronchial asthma reduces the risk of exacerbation of cardiovascular diseases. The use of ICS/SABA becomes more justified in the presence of the Arg16Gly allele of the ADRB2 receptor gene, which suggests a better response to SABA comparatively to long-acting β2-agonists.Kupaev V.I., Pokhaznikova M.A., Degtyareva L.N.
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References
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About the Authors
Vitaly I. Kupaev, MD, Dr. Sci. (Medicine), professor of the Department of family medicine, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.E-mail: vk1964sam@rambler.ru
ORCID: https://orcid.org/0000-0003-2639-0003. Scopus ID: 23985153900. eLibrary SPIN: 1458-5872
Marina A. Pokhaznikova, MD, PhD (Medicine), associate professor of the Department of family medicine, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: Marina.Pokhaznikova@szgmu.ru
ORCID: https://orcid.org/0000-0001-9894-5974. eLibrary SPIN: 3387-0226
Lyudmila N. Degtyareva, MD, PhD (Medicine), associate professor of the Department of family medicine, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: ludmila.degtyareva@szgmu.ru
ORCID: https://orcid.org/0000-0001-8375-3363. eLibrary SPIN: 5942-8540