Acetylsalicylic acid for the treatment of patients with cardiovascular diseases: New data, clinical guidelines and practical aspects
Abstract. Millions of patients with cardiovascular diseases receive acetylsalicylic acid (ASA), but some of them have acute events despite the drug therapy. One of the backgrounds for the development of cardiovascular events in groups of increased cardiovascular risk may be the lack of response to standard low doses of ASA. In recent years, possible causes and risk factors for this phenomenon have been actively discussed, including its connection with the presence of an enteric coating in ASA drugs, as well as possible ways to overcome it by identifying the most vulnerable groups of patients for whom it is preferable to prescribe certain forms of ASA or individual dose selection. The article discusses new clinical studies devoted to this problem and the corresponding changes in the recommendation documents.Pisaryuk A.S., Ly X.P., Amirova A.N., Kobalava Zh.D.
Keywords
lack of response to acetylsalicylic acid
interindividual variability in response to acetylsalicylic acid
platelet function testing
platelet functional activity
monitoring of antiplatelet therapy
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About the Authors
Alexandra S. Pisaryuk, MD, PhD (Medicine), associate professor of the Department of internal medicine with a course in cardiology and functional diagnostics named after academician V.S. Moiseyev of the Medical institute, RUDN University, cardiologist at the resuscitation and intensive care unit for cardiology patients, V.V. Vinogradov University Clinical Hospital (branch) of RUDN University. Address: 117198, Moscow, 6 Mikloukho-Maklaya St.E-mail: pisaryuk_as@pfur.ru
ORCID: https://orcid.org/0000-0003-4103-4322. eLibrary SPIN: 5602-1059
Xong Pha Ly, MD, postgraduate student of the Department of internal medicine with the course of cardiology and functional diagnostics named after academician V.S. Moiseyev of the Medical institute, RUDN University. Address: 117198, Moscow, 6 Mikloukho-Maklaya St.
E-mail: lyxongpha@mail.ru
ORCID: https://orcid.org/0009-0004-0211-9678
Aliya N. Amirova, MD, postgraduate student of the Department of internal medicine with the course of cardiology and functional diagnostics named after academician V.S. Moiseyev of the Medical institute, RUDN University. Address: 117198, Moscow, 6 Mikloukho-Maklaya St.
E-mail: amirova-86@inbox.ru
ORCID: https://orcid.org/0009-0000-2474-7297. eLibrary SPIN: 4863-3280
Zhanna D. Kobalava, MD, Dr. Sci. (Medicine), professor, corresponding member of RAS, head of the Department of internal medicine with a course in cardiology and functional diagnostics named after academician V.S. Moiseyev of the Medical institute, RUDN University, head of V.V. Vinogradov University Clinical Hospital (branch) RUDN University. Address: 117198, Moscow, 6 Mikloukho-Maklaya St.
E-mail: zkobalava@mail.ru
ORCID: https://orcid.org/0000-0002-5873-1768. Scopus ID: 7004399203. eLibrary SPIN: 9828-5409
